Results 71 to 80 of about 575,763 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Digital technologies in the diagnosis and treatment of neurological diseases

Неврология, нейропсихиатрия, психосоматика, 2019
The review considers works devoted to convolutional neural networks as a main method for digital image processing, as well as to the diagnosis of neurological diseases based on computer-aided analysis of magnetic resonance imaging and ...
N. V. Petukhova, M. P. Farkhadov, M. V. Zamegrad, S. P. Grachev   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The potential of a targeted unilateral compound training program to reduce lower limb strength asymmetry and increase performance: a proof-of-concept in basketball

Frontiers in Physiology
ObjectiveThis study investigates the efficacy of training methodologies aimed at mitigating asymmetries in lower limb strength and explosiveness among basketball players.MethodsThirty male university basketball athletes were enrolled in this research ...
Wenfeng Zhang, Wenfeng Zhang, Xing Chen, Kun Xu, Hezhi Xie, Jiayong Chen, Ziwei Zhu, Hongshen Ji, Duanying Li, Duanying Li, Jian Sun, Jian Sun   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Assessment of dynamic stability and identification of key tasks and parameters in patients with unilateral and bilateral vestibulopathy: a laboratory-based study

Frontiers in Neuroscience
Chronic imbalance is the cardinal symptom in bilateral vestibulopathy patients (BV), and in a subset of symptomatic unilateral vestibulopathy patients (UV), leading to a significant impact on their daily lives. Despite these profound effects, such as the
Gautier Grouvel, Gautier Grouvel, Gautier Grouvel, Anissa Boutabla, Julie Corre, Romain Bechet, Samuel Cavuscens, Maurizio Ranieri, Jean-François Cugnot, Christopher McCrum, Raymond van de Berg, Nils Guinand, Stéphane Armand, Stéphane Armand, Angélica Pérez Fornos   +14 more
doaj   +1 more source

Morcellement identitaire intergénérationnel dans le roman Les deux sœurs de Dominique Rolin [PDF]

Revue Roumaine d’Etudes Francophones, 2020
As a major component of the narrative, the identity occupies an increasingly important place in the 20th century novel’s writing. The multiple facets of the Rolinian creative insight let flow the story in the novel The Two Sisters.
Ema-Violeta MISTRIANU
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology
Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
doaj   +1 more source