Results 221 to 230 of about 46,171 (307)

Machine learning-based unified models for predicting drug clearance from pharmacokinetic animal and study design variables. [PDF]

PLoS One
Ampadi Ramachandran R, Tell LA, Mercer MA, Xu X, Millagaha Gedara NI, Clapham MO, Lin Z, Riviere JE, Jaberi-Douraki M.   +8 more
europepmc   +1 more source

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Advanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, Heping Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen   +15 more
wiley   +1 more source

GVD: general violence detection via semantic differentiation and orthogonal supervision. [PDF]

Sci Rep
Tan M, Liu R, Zhou S, Zheng Q, Lin L.
europepmc   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Step-Wise Dual Dynamic DPSGD: Enhancing Performance on Imbalanced Medical Datasets with Differential Privacy. [PDF]

Entropy (Basel)
Huang X, Xie F.
europepmc   +1 more source

Imaging Electric Polarization Switching in Multilayer Graphene

Advanced Science, EarlyView.
Domain wall sliding‐induced electric polarization switching is directly observed for the first time in multilayer graphene, enabled by a novel optical readout method. The polarization switching is realized upon application of global and local electric fields, and mechanical forces between neighboring polar domains of opposite out‐of‐plane polarizations
Zhou Zhou, Xiyao Peng, Jianfeng Bi, Jing He, Fei Xue, Jie Jiang, Huizhen Wu, Zhiwen Shi, Haoliang Qian, Toshikaze Kariyado, Sihan Zhao   +10 more
wiley   +1 more source

Enhanced classification approach using MI-SVM for imbalanced multi-class datasets. [PDF]

Sci Rep
Patel V, Bhavsar H.
europepmc   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Vision-Based Environmental Sensing for Flood Risk Forecasting: Dataset Relabeling and Temporal Multi-Task Learning. [PDF]

Sensors (Basel)
Lee S, Park G.
europepmc   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source