Results 371 to 380 of about 106,252 (402)

Imidazole anticonvulsants: structure-activity relationships of [(biphenylyloxy)alkyl]imidazoles

Journal of Medicinal Chemistry, 1987
The [(biphenylyloxy)alkyl]imidazoles were found to be potent anticonvulsants. The most potent compound of the series, 1-[2- ([1,1'-biphenyl]-2-yloxy)ethyl]-1H-imidazole (4), had an ED50 of 15.5 mg/kg against maximal-electroshock-induced seizures in mice after oral administration; the horizontal screen ED50 was 320 mg/kg, revealing that the compound has
J D Leander, David W. Robertson, R.R. Lawson, E. E. Beedle   +3 more
openaire   +3 more sources

ZrO2-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study

, 2015
A series of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles catalyzed by ZrO2-supported-β-cyclodextrin (ZrO2-β-CD) under solvent free conditions have been synthesized and characterized by spectral methods.
Yarabhally R. Girish, K. S. S. Kumar, K. N. Thimmaiah, K. Rangappa, S. Shashikanth   +4 more
semanticscholar   +1 more source

Imidazoles and benzimidazoles

1998
The parent compound imidazole (1) was first synthesized in 1858 by Debus but imidazole derivatives were known before this, e.g. lophine (2,4,5-triphenylimidazole) (2) was synthesized in 1845 by Laurent.
openaire   +2 more sources

Zeolite A imidazolate frameworks

Nature Materials, 2007
Faujasite (FAU) and zeolite A (LTA) are technologically important porous zeolites (aluminosilicates) because of their extensive use in petroleum cracking and water softening. Introducing organic units and transition metals into the backbone of these types of zeolite allows us to expand their pore structures, enhance their functionality and access new ...
Hideki, Hayashi, Adrien P, Côté, Hiroyasu, Furukawa, Michael, O'Keeffe, Omar M, Yaghi   +4 more
openaire   +2 more sources

Synthesis of imidazoles via cascade reaction of nitroallylic acetates with amidines and studies on their trypanocidal activity.

Organic and biomolecular chemistry, 2015
A one-pot, two step synthesis of highly substituted imidazoles has been carried out in good to excellent yields for the first time via a cascade intermolecular aza-SN2'-intramolecular aza-Michael addition involving a variety of Morita-Baylis-Hillman ...
T. Kumar, D. Verma, R. S. Menna-Barreto, Wagner O Valença, Eufrânio N. da Silva Júnior, I. Namboothiri   +5 more
semanticscholar   +1 more source

New Methods of Imidazole Functionalization - From Imidazole to Marine Alkaloids

Synlett, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yong He, Hongwang Du, Rasapalli Sivappa, Carl J. Lovely   +3 more
openaire   +3 more sources

Multicomponent synthesis of substituted and fused-ring imidazoles via phospha-münchnone cycloaddition.

Journal of Organic Chemistry, 2015
A new, one-pot synthesis of imidazoles from imines, acid chlorides, and N-nosyl imines or tethered nitriles is reported. The reaction is mediated by the phosphonite PPh(catechyl) and proceeds via regioselective cycloaddition with an in situ-generated ...
S. Aly, Mikhail D. Romashko, B. Arndtsen
semanticscholar   +1 more source

Analysis of intermolecular interaction energy inputs in benzene-imidazole and imidazole-imidazole systems in parallel displaced and T-configuration

Biophysics, 2013
Intermolecular interactions in several dimer aromatic systems were analyzed to determine how various energy contributions (electrostatic, exchange, repulsion, and polarization) change depending on the value of monomers separation. Different contributions to the intermolecular energy interactions between imidazole-imidazole and benzene-imidazole dimers ...
M. L. McKee, Aleksandr V. Zhuravlev, B. F. Shchegolev, E. V. Savvateeva-Popova   +3 more
openaire   +3 more sources

Iron(III)/Iodine‐Catalyzed C(sp2)H Activation of α,β‐Unsaturated Aldehydes/Ketones with Amidines: Synthesis of 1,2,4,5‐Tetrasubstituted Imidazoles

, 2015
An efficient methodology to access a library of 1,2,4,5-tetrasubstituted imidazoles from a broad range of amidines and ,β-unsaturated aldehydes/ketones via a C( sp 2 ) H amination has been developed. This method represents a new and simple way to prepare
Ping Wu, J. Qu, Yaxuan Li, Xin Guo, Dong Tang, Xu Meng, Rulong Yan, Baohua Chen   +7 more
semanticscholar   +1 more source

Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir

, 2015
Herein we present a high-temperature/high-pressure continuous flow synthesis of 1H-4-substituted imidazoles starting from α-bromoacetophenones and carboxylic acids.
Paula F. Carneiro, Bernhard Gutmann, Rodrigo O. M. A. de Souza, C. Kappe   +3 more
semanticscholar   +1 more source