Results 111 to 120 of about 24,870 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the thermal ecology of two coexisting lizard species (Reptilia, Lacertidae) in a hot and dry area of Bulgaria [PDF]

Herpetozoa
Thermal ecology plays a key role in shaping the behavior and distribution of reptiles, particularly under climate stress. Understanding how sympatric lizard species manage their thermal preferences is essential for predicting their responses to changing ...
Emiliya Vacheva, Nikola Stanchev, Georgi Krastev, Angel Dyugmedzhiev, Borislav Naumov   +4 more
doaj   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Anterolateral augmentation procedures during anterior cruciate ligament reconstructions in skeletally immature patients: Scoping review of surgical techniques and outcomes

Journal of Experimental Orthopaedics
Purpose Graft failure rates after anterior cruciate ligament reconstruction (ACLR) in children and adolescents are higher compared to adults. Anterolateral augmentation procedures have recently generated increased focus regarding their ability to reduce ...
Martijn Dietvorst, Stéphanie Verhagen, Marieke C. van derSteen, Florens Q. M. P. vanDouveren, Rob P. A. Janssen   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Impact de la commercialisation des poissons immatures et adultes sur la gestion durable de la diversité ichtyologique dans le Pool Malebo (Fleuve Congo), Kinshasa, République Démocratique du Congo

Revue Congolaise des Sciences et Technologies
Les écosystèmes aquatiques constituent des réservoirs vitaux de ressources biologiques, indispensables à la subsistance des populations humaines. Leur exploitation rationnelle s’impose aujourd’hui comme une nécessité pour assurer la durabilité des ...
Yves Aseke Lukuke, Cush Luwesi Ngonzo, Godé Bosongo Bola, Génie-Spirou Kiala Lutonadio, Patience Mpia Ngelinkoto, Pascal Masawula Kazwenga, Marcel Adoko Bagala, Landry Nzamipiele Nkaba, Raphael Muamba Tshimanga   +8 more
doaj   +1 more source

Evaluation of pirimiphos-methyl (50% EC) against the immatures of Anopheles stephensi/An. culicifacies (malaria vectors) and Culex quinquefasciatus (vector of bancroftian filariasis) [PDF]

Journal of Vector Borne Diseases, 2004
Background & objectives : In India, temephos and fenthion are used as larvicides in fresh andpolluted waters. Since use of same insecticide may precipitate resistant, as an alternative bioefficacyof pirimiphos-methyl—an organophosphorus insecticide was ...
M.A. Ansaria, P.K. Mittal, R.K. Razdan, R.C. Dhiman & A. Kumar
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Description of the last nymphal instar of Talipes appendiculatus (Hemiptera: Membracidae: Membracinae), and notes on the biology of the immatures and adults

Zoologia (Curitiba)
The last instar nymph of Talipes appendiculatus (Fonseca) is described and illustrated, and biological data are given on the immatures and adults. The 5th instar nymph has the body covered with tuberculate chalazae; head and thorax without scoli; abdomen
Frederico Lencioni-Neto, Albino M. Sakakibara   +1 more
doaj   +1 more source