Results 41 to 50 of about 95,964 (260)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Effect of immersion frequency on shoot multiplication of Bambusa vulgaris Schrader ex Wendland in RITA^® TIS

Biotecnología Vegetal, 2013
Bamboos are unique in bringing together a wide range of environmental services. The present work was conducted to determine the effect of immersion frequency of shoot multiplication of B. vulgaris grown in SIT. Three Immersion frequencies (every 4, 6 and
Yudith García-Ramírez, Mallelyn González-González, Marisol Freire-Seijo, Mariana La O, Berkis Roque, Ortelio Hurtado, Eilyn Mena   +6 more
doaj  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Optimization of photoperiod and immersion frequency in an IoT-integrated Temporary Immersion System for enhanced growth and reduced contamination of Coelogyne pandurata culture

Journal of the Saudi Society of Agricultural Sciences
The integration of Internet of Things (IoT) technology into a Temporary Immersion System (TIS) was studied for micropropagation of the endangered black orchid, Coelogyne pandurata.
Irma Jamaluddin, Rinaldi Sjahril, Elkawakib Syam‘un, Feranita Haring, Novianti Sampepadang   +4 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Multiplication of Ipomoea batatas clon ‘INIVITB2-2005’ in Temporary Inmersion Systems

Biotecnología Vegetal, 2008
Use of temporary immersion system (TIS) have been not reported for in vitro culture of Ipomoea batatas . This technique would help to increase the number of plants needed for in vitro mass propagation of clone ‘INIVITB2-2005’ with great productive ...
Milagros Basail Pérez, Víctor Medero Vega, Manuel Cabrera Jova, Arletys Santos Pino, Marlenys Torres Delgado, Eneida Otero Gálvez, Alexi Ortega Ortiz, Jorge López Torres, Aymé Rayas Cabrera, Yoel Beovides García, Eriker Paz Chávez   +10 more
doaj  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

In vitro multiplication of plantain cv. ‘INIVIT PV-2011’ (Musa AAB) in Temporary Immersion System

Biotecnología Vegetal, 2015
The work was developed in the laboratory of Plant Biotechnology at Instituto de Investigaciones de Viandas Tropicales (INIVIT) with the aim of multiplying the plantain cultivar ‘INIVIT PV-2011’ (Musa AAB) in Temporary Immersion Systems (10.0 liters ...
Milagros Basail Pérez, Victor Medero Vega, Yenisey Gutiérrez Sánchez   +2 more
doaj  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source