Results 101 to 110 of about 400,609 (337)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Work-in-progress—immersive learning:challenges and trends [PDF]

Immersive technologies provide innovative opportunities for interactive and engaging learning taking advantage of real-world scenarios and simulations to provide practical situations for learners, helping them better prepare for real-world challenges and
Bagheri Baba Ahmadi, Sajjad; id_orcid, Gilardi, Marco; id_orcid   +1 more
core   +1 more source

Immersions of manifolds [PDF]

Transactions of the American Mathematical Society, 1959
IMMERSIONS OF MANIFOLDSC) BY MORRIS W. HIRSCH Introduction Let M and N be differentiable manifolds of dimensions k and n respec- tively, k N is called an immersion if / is of class C1 and the Jacobian matrix of/ has rank k at each point of M. Such a map is also called regular.
openaire   +4 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Interaction for Immersive Analytics [PDF]

, 2018
International audienceIn this chapter, we briefly review the development of natural user interfaces and discuss their role in providing human-computer interaction that is immersive in various ways.
Kerren, Andreas,, Tim Dwyer, Dwyer, Tim, Andreas Kerren, Steven Drucker, Wolfgang Stuerzlinger, Görg, Carsten,, Drucker, Steven,, Drucker, Steven, M., Wolfgang Büschel, Raimund Dachselt, Dachselt, Raimund,, Görg, Carsten, Stuerzlinger, Wolfgang,, Büschel, Wolfgang, Chen, Jian,, Dwyer, Tim,, Kerren, Andreas, Stuerzlinger, Wolfgang, Chen, Jian, Tobias Isenberg, Chris North, Isenberg, Tobias,, North, Chris,, Büschel, Wolfgang,, Jian Chen, North, Chris, Carsten Görg, Isenberg, Tobias, Dachselt, Raimund   +29 more
core   +1 more source

IMMERSIVE TECHNOLOGIES IN HEALTHCARE TRAINING & EDUCATION: THREE PRINCIPLES FOR PROGRESS

, 2021
This report highlights 3 principles through which progress in this area can be accelerated. These principles are: 1. The design and development of immersive tools that are driven by learning requirements, and informed by the science of human behaviour ...
Centre for Immersive Technologies, Faisal Mushtaq   +1 more
core   +1 more source

Subjugating Other Cultural Narratives in the Construction of Immersive Environments

Body, Space & Technology Journal, 2020
This Paper feeds into the current transcultural debate surrounding tensions between the construction of immersive technologies within westernised paradigms.
Olu Taiwo
doaj   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source