Results 301 to 310 of about 2,310,619 (425)
DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics
Advanced Science, EarlyView.A molecular computing approach is presented with weighted signal amplification. Polymerase‐mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly.
Hongyang Zhao +6 more
wiley +1 more source
Advanced Science, EarlyView.An atomic‐level engineered ruthenium single‐atom nanozyme is fabricated that features sufficient oxygen vacancies and electron and hole separation efficiency, which enhances response to the sono‐suppressive tumor microenvironment and induces tumor ferroptosis.
Yang Zhu +14 more
wiley +1 more source
Advanced Science, EarlyView.A calcium‐dependent, specific biorecognition between coagulation factor Xa (FXa) and zeolite is discovered. It alters the prothrombin activation pathway to a more efficient mechanism by mimicking the FXa/factor Va (FXa/FVa) interaction formed during the natural coagulation cascade.
Chaojie Shi +9 more
wiley +1 more source
Advanced Science, EarlyView.This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu +8 more
wiley +1 more source
Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
, 2000 Mark T. Cancilla +3 more
openalex +1 more source
Advanced Science, EarlyView.A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li +21 more
wiley +1 more source
Preparation of silica with controlled pore sizes for enzyme immobilization
, 2000 Henrique C. Trevisan +2 more
openalex +1 more source
Microneedle Patch for In Situ Neutrophil Monitoring
Advanced Science, EarlyView.An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu +26 more
wiley +1 more source