Results 101 to 110 of about 1,171,277 (292)

Clinical and Laboratory Analysis of Children Who Follow Up with Thrombocytopenia: A Retrospective Study

Güncel Pediatri
Introduction: Platelets are cells that play an important role in the first phase of hemostasis, where the clot plug is formed. Disorders in the number or function of platelets can lead to bleeding.
Yasemin Denkboy Öngen, Birol Baytan
doaj   +1 more source

Metronidazole caused profound drug‐induced immune thrombocytopenia

Clinical Case Reports, 2018
Key Clinical Message Metronidazole is commonly prescribed and has not been known to cause drug‐induced immune thrombocytopenia. We have provided clinical and laboratory evidence with DDabs that metronidazole can cause drug‐induced immune thrombocytopenia
Jeffrey Lew, Jeffrey Berenberg
doaj   +1 more source

Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever

Case Reports in Oncology, 2017
Primary immune thrombocytopenia (ITP) – also called idiopathic thrombocytopenic purpura or immune thrombocytopenic purpura – is an acquired thrombocytopenia caused by autoantibodies against platelet antigens.
Cherisse Baldeo, Karan Seegobin, Lara Zuberi   +2 more
doaj   +1 more source

A Practical Guide to Implementing Real‐World Evidence as Primary Basis for Approval and Label Expansion

Clinical Pharmacology &Therapeutics, EarlyView.
In June 2026, the FDA issued a revised draft guidance describing the circumstances in which one adequate and well‐controlled clinical investigation plus confirmatory evidence may satisfy the statutory substantial evidence standard for establishing efficacy and safety. Confirmatory evidence includes real‐world evidence (RWE).
Tracy J. Mayne, Maurice A. Brookhart, Nancy A. Dreyer   +2 more
wiley   +1 more source

Quinidine-Induced Immune Thrombocytopenia [PDF]

, 1989
We have identified six cases of quinidine-induced immune thrombocytopenia based on clinical evidence and in association with elevated amounts of platelet surface IgG.
LoBuglio, Albert, Dhodaphar, Nadhav, Saleh, Mansoor, Allen, Karen, Allen, Karren, Saleh, Mansoor N., LoBuglio, Albert F.   +6 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Successful Treatment of Steroid-Refractory Immune Thrombocytopenia in a Patient Developing Multiple Myeloma While on Immune Checkpoint Inhibitor Therapy for Lung Cancer: A Case Report [PDF]

Yudai Hayashi,* Masao Tsukada,* Daisuke Shinoda, Marina Matsui, Kanichi Iwama, Koichi Kajiwara, Kozai Yasuji Department of Hematology, Tokyo Metropolitan Tama Medical Center, Fuchu City, Tokyo, Japan*These authors contributed equally to this ...
Matsui M, Kajiwara K, Yasuji K, Hayashi Y, Iwama K, Tsukada M, Shinoda D   +6 more
core  

Clinical Experience With Eliglustat in Children With Gaucher Disease Type 1

American Journal of Medical Genetics Part A, EarlyView.
Erika R. Vucko, Allegra Quadri, Rachel E. Hickey, Carly A. Rasmussen, Monika Izdebski, Joel Charrow, Carlos E. Prada   +6 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia

Haematologica, 2017
Primary immune thrombocytopenia is an autoimmune disorder characterized by increased platelet destruction and insufficient platelet production without another identified underlying disorder.
Douglas B. Cines, Jeffrey Wasser, Francesco Rodeghiero, Beng H. Chong, Michael Steurer, Drew Provan, Roger Lyons, Jaime Garcia-Chavez, Nancy Carpenter, Xuena Wang, Melissa Eisen   +10 more
doaj   +1 more source