Results 221 to 230 of about 86,262 (260)
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Immune Thrombocytopenia Treatment
New England Journal of Medicine, 2021Idiopathic thrombocytopenia (ITP) has a long history. In 1025, Avicenna described in the Canon of Medicine a patient with characteristics of ITP, which became known as “idiopathic thrombocytopenic ...
Paula H.B. Bolton-Maggs, James N. George
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Hospital Practice, 1983
The common denominator of this group of disorders is bleeding due to antibody-mediated platelet destruction. The variations in clinical manifestation--ranging from mild to fatal--reflect the diverse origins of the troublesome antibodies: transplacental, exogenous, and autogenous.
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The common denominator of this group of disorders is bleeding due to antibody-mediated platelet destruction. The variations in clinical manifestation--ranging from mild to fatal--reflect the diverse origins of the troublesome antibodies: transplacental, exogenous, and autogenous.
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Pathogenesis of immune thrombocytopenia
La Presse Médicale, 2014Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection ...
Douglas B, Cines +2 more
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GESTATIONAL THROMBOCYTOPENIA AND IMMUNE THROMBOCYTOPENIAS IN PREGNANCY
Hematology/Oncology Clinics of North America, 2000Appropriate management of thrombocytopenia in the pregnant patient is important for the well-being of both mother and fetus. The healthy-appearing mother with mild thrombocytopenia may have either gestational benign thrombocytopenia, which does not produce fetal thrombocytopenia, or immune-mediated thrombocytopenia, which can produce fetal ...
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Immunopathology of immune thrombocytopenia
Journal of Thrombosis and HaemostasisImmune thrombocytopenia (ITP) is an acquired bleeding disorder caused by complex immune dysregulation. ITP is a rare disorder with significant morbidity; patients experience bleeding symptoms and reduced quality of life. The pathogenesis of ITP can be observed at several levels: the mechanisms of thrombocytopenia, the loss of tolerance mechanisms, and ...
Kirsty Hillier +2 more
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Pathogenesis of immune thrombocytopenia
Autoimmunity Reviews, 2017Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell response, notably supported by splenic T follicular helper cells, that stimulates the proliferation and differentiation of autoreactive B cells. The antiplatelet autoantibodies they produce facilitate platelet phagocytosis by macrophages, essentially in the spleen ...
Sylvain, Audia +4 more
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Immune thrombocytopenia in children
Journal of Pediatric Hematology/Oncology, 1981Idiopathic thrombocytopenic purpura in the adult has a clearly established autoimmune etiology; IgG antiplatelet antibody is demonstrable on the patient's platelets and is frequently present in the serum. Platelet IgG is correlated inversely with the platelet count.
M, Karpatkin, S, Karpatkin
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Pathophysiology of immune thrombocytopenia
Current Opinion in Hematology, 2018Purpose of review Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder with as of yet, no established clinical prognostic or diagnostic biomarkers. Patients frequently experience a markedly decreased quality of life and may be at risk for severe/fatal haemorrhage.
June, Li, Jade A, Sullivan, Heyu, Ni
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Other Immune Thrombocytopenias
Seminars in Hematology, 2007Immune thrombocytopenic purpura (ITP) can be classified as primary (known also as idiopathic thrombocytopenic purpura) or as secondary to an underlying condition such as a malignant or nonmalignant disorder. Commonly occurring conditions associated with secondary ITP include lymphoproliferative disorders (chronic lymphocytic leukemia [CLL], Hodgkin's ...
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Malaria-Induced Immune Thrombocytopenia
Vox Sanguinis, 1984Abstract. On return from Liberia, a previously healthy 36‐year‐old man showed signs of malaria accompanied by severe haemolysis and slight thrombocytopenia. We found evidence of a platelet‐associated IgG being responsible for the thrombocytopenia, inasmuch as the direct platelet suspension immunofluorescence test was strongly positive, the indirect ...
Sørensen, P G, Mickley, H, Schmidt, K G
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