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Immunopathology of immune thrombocytopenia
Journal of Thrombosis and HaemostasisImmune thrombocytopenia (ITP) is an acquired bleeding disorder caused by complex immune dysregulation. ITP is a rare disorder with significant morbidity; patients experience bleeding symptoms and reduced quality of life. The pathogenesis of ITP can be observed at several levels: the mechanisms of thrombocytopenia, the loss of tolerance mechanisms, and ...
Kirsty Hillier +2 more
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Pathogenesis of immune thrombocytopenia
La Presse Médicale, 2014Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection ...
Douglas B, Cines +2 more
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Malaria-Induced Immune Thrombocytopenia
Vox Sanguinis, 1984Abstract. On return from Liberia, a previously healthy 36‐year‐old man showed signs of malaria accompanied by severe haemolysis and slight thrombocytopenia. We found evidence of a platelet‐associated IgG being responsible for the thrombocytopenia, inasmuch as the direct platelet suspension immunofluorescence test was strongly positive, the indirect ...
Sørensen, P G, Mickley, H, Schmidt, K G
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Immune Thrombocytopenia in Lymphoproliferative Disorders
Hematology/Oncology Clinics of North America, 2009Lymphoproliferative disorders are recognized as a common cause of secondary immune thrombocytopenia (ITP). The mechanisms involved in the pathogenesis of ITP associated with lymphoproliferative disorders are heterogeneous and often linked to the presence and activity of the malignant clone.
Visco, Carlo, Rodeghiero, Francesco
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Pediatric Immune Thrombocytopenia
Advances in PediatricsPediatric immune thrombocytopenia (ITP) is a fairly common bleeding disorder PRESENTING with a decreased number of platelets. The typical clinical presentation involves mild bleeding symptoms with bruising and petechiae and occasional mucosal bleeding.
Moran, Gotesman +4 more
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Rilzabrutinib in Immune Thrombocytopenia
New England Journal of Medicine, 2022Jun, Murakami +2 more
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Rilzabrutinib for immune thrombocytopenia
Nature Cardiovascular Research, 2022openaire +2 more sources
Update on diagnosis and treatment of immune thrombocytopenia
Expert Review of Clinical Pharmacology, 2021Kamal Kant Sahu +2 more
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