Results 51 to 60 of about 1,171,277 (292)

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

The Epidemiology of Immune Thrombocytopenia

Canadian Journal of Infectious Diseases and Medical Microbiology, 1991
Three cases of immune thrombocytopenia (ITP) associated with human immunodeficiency virus (HIV) infection prompted a review of community‐acquired thrombocytopenia in Nova Scotia from January 1980 to December 1987. Two hundred and seven patients meeting the case definition of ITP were identified. The incidence of ITP rose from 2.0×105 in 1980 to 3.3×105
Walter F Schlech, Christine Nesdoly, Nancy Meagher, Janet Turner, Donalda Dickey   +4 more
openaire   +3 more sources

Innate and Adaptive Immunity in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP.
Alan H, Lazarus, John W, Semple, Douglas B, Cines   +2 more
openaire   +2 more sources

Immune thrombocytopenia

International journal of health sciences, 2022
An inherited condition with isolated thrombocytopenia, immune thrombocytopenia (ITP) is still unknown in terms of the cause. A primary or secondary ITP diagnosis is determined by whether or not an underlying treatable cause exists. Diagnosis of primary ITP is based on the exclusion and hence does not have a gold standard test to validate it.
Avijit Mazumder, Saumya Das, Ayush Atri, Komal Singh, Madhvi Singh   +4 more
openaire   +1 more source

Serum D vitamin levels in children with immune thrombocytopenia

, 2019
Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by thrombocytopenia with an increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as an immune modulator.
Gallone, Maria Filomena, Russo, Giovanna, Palmieri, Viviana, Tafuri, Silvio, AMORUSO, ANNA, Lassandro, Giuseppe, Carriero, Francesco, Del Vecchio, Giovanni Carlo, Giordano, Paola, Palladino, Valentina   +9 more
core   +1 more source

Can Anti-Thyroid Antibodies Influence the Outcome of Primary Chronic Immune Thrombocytopenia in Children?

, 2020
Immune thrombocytopenia (ITP) is an acquired immune mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients can develop autoantibodies such as anti-thyroglobulin (TG) and anti-thyroperoxidase (TPO), even in absence of ...
Faienza, Maria Felicia, Chiarito, Mariangela, Delvecchio, Maurizio, Lassandro, Giuseppe, Wasniewska, Malgorzata, Giordano, Paola, Valente, Federica, Palladino, Valentina   +7 more
core   +1 more source

Mycophenolate Mofetil for first-line treatment of Immune Thrombocytopenia

, 2021
BACKGROUND: Immune thrombocytopenia (ITP) is a rare autoimmune thrombocytopenia with associated bleeding risk and fatigue. Recommended first line ITP treatment is with high dose glucocorticoids but side effects, heterogeneous responses and high relapse ...
Talks, Kate, Bradbury, Charlotte A., Ingram, Jenny, Rayment, Rachel, Hill, Quentin, Bagot, Catherine, Pell, Julie, Kandiyali, Rebecca, Breheny, Katie, Evans, Gillian, Greenwood, Rosemary, Cooper, Nichola, Thomas, Ian   +12 more
core   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Cell death in immune thrombocytopenia: novel insights and perspectives [PDF]

, 2013
Immune thrombocytopenia (ITP) is a complex disease. The pathogenic and clinical heterogeneity of ITP is reflected by reports on variability in patient history and treatment response, in concert with recent evidence from mechanistic studies.
Simon, Hans-Uwe, Hans-Uwe Simon, Marc Wehrli, Stephan von Gunten, Wehrli, Marc, von Gunten, Stephan   +5 more
core   +2 more sources

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source