Results 101 to 110 of about 52,797 (313)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Author Correction: Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England

Nature Communications, 2022
Gayatri Amirthalingam, Jamie Lopez Bernal, Nick J. Andrews, Heather Whitaker, Charlotte Gower, Julia Stowe, Elise Tessier, Sathyavani Subbarao, Georgina Ireland, Frances Baawuah, Ezra Linley, Lenesha Warrener, Michelle O’Brien, Corinne Whillock, Paul Moss, Shamez N. Ladhani, Kevin E. Brown, Mary E. Ramsay   +17 more
doaj   +1 more source

Influence Of Health Behaviour Factors On Basic Immunisation In Indonesia 2022

Saintika Medika
Background: The coverage of complete basic immunisation in Indonesia from 2020 to 2022 never reached the target of the 2020-2024 National Medium-Term Development Plan despite various efforts made by the government.
Syifa Faikhatul Ilmi, Efri Diah Utami
doaj   +1 more source

Immunisation for refugees in Australia: a policy review and analysis across all States and Territories

Australian and New Zealand Journal of Public Health, 2017
Objective: Although people of refugee background are likely to be under‐immunised before and after resettlement, no study to date has evaluated refugee specific immunisation policies in Australia. We developed a framework to analyse immunisation policies
Abela Mahimbo, Holly Seale, Anita E. Heywood   +2 more
doaj   +1 more source

The impact of a vaccine scare on parental views, trust and information needs: a qualitative study in Sydney, Australia

BMC Public Health, 2017
Background Vaccine safety scares can undermine public confidence in vaccines and decrease immunisation rates. Understanding and addressing parental concerns arising during such scares can assist in lessening their impact. In Australia in April 2010 there
Catherine King, Julie Leask
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

School-based influenza immunisation programme pilot: Using an out-of-hours model

, 2016
Influenza is a common and potentially serious viral infection. The Joint Committee of Vacination and Immunisation recommended that the seasonal influenza programme should be expanded in 2012 to include all children from the ages of 2–17 years in ...
Blackadder, Ayleen, Young, Patricia, Robertson, Deborah, Gourlay, Sandra, Robertson, Calum, Penman, Shona, Robertson, Shirley, Stoddart, Kathleen, Hinton, Shona, Osborne, Michele   +9 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Mass Immunisation Programmes: Some Philosophical Issues

, 1998
Most countries promote mass immunisation programmes. The varying policy details raise a raft of philosophical issues. I have two broad aims in this paper. First, I hope to begin to remedy a rather curious philosophical neglect of immunisation.
Dare, Tim
core   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source