Results 131 to 140 of about 2,030,178 (334)

A Michaelis‐Arbuzov‐Type Pathway to a Protected 2ʹ‐Deoxy‐2ʹ‐Selenomethyl‐Adenosine‐3ʹ,5ʹ‐Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis

open access: yesChemistry – A European Journal, EarlyView.
Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale   +2 more
wiley   +1 more source

Strategic Spatiotemporal Vaccine Distribution Increases the Survival Rate in an Infectious Disease like Covid-19

open access: yes, 2020
Covid-19 has caused hundred of thousands of deaths and an economic damage amounting to trillions of dollars, creating a desire for the rapid development of vaccine.
Grauer, Jens   +2 more
core   +1 more source

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

open access: yesChemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin   +3 more
wiley   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

open access: yesCytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves   +3 more
wiley   +1 more source

Alignment and Differentiation: How Language and Network Proximity Drive Opinion‐Based Group Formation Online

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT This study examines the interplay between language and social connectedness in forming opinion‐based groups on social media. Drawing on small‐world theory and social identity theory, we propose a dual‐layer approach that combines semantic and network analysis to investigate the dynamics of group formation on X/Twitter during the 2021 COVID‐19 ...
Davide Morselli   +8 more
wiley   +1 more source

Reclaimed Homophobic Hate Speech Backfires: Desensitization and Mood Deterioration

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT Reclaimed hate speech is generally seen as a positive phenomenon by minority groups and, to some degree, by majority groups. However, previous research has not examined whether it might produce harmful effects similar to traditional hate speech.
Dominik Puchała   +2 more
wiley   +1 more source

Measles targets and herd immunity [PDF]

open access: yesBritish Journal of General Practice, 2013
Measles epidemics occur in populations with sufficient numbers of susceptible individuals for each infected person to meet and pass on the virus to one or more other susceptible individuals. Herd immunity suggests that if enough people are rendered immune such meetings will be rare enough for the virus not to be passed on and the whole population to be
openaire   +2 more sources

A Comprehensive Review of Biotechnological Innovations in Valorization of Food Waste: Enhancing Nutritional, Techno‐Functional Properties, and Process Optimization for Sustainable Product Development

open access: yesFood Frontiers, EarlyView.
This review highlights recent biotechnological innovations in the valorization of food waste through enzyme‐assisted processing and microbial fermentation to enhance nutritional, techno‐functional, and shelf‐stable properties for developing sustainable, plant‐based functional foods and nutraceuticals.
Md. Sakhawot Hossain   +6 more
wiley   +1 more source

Enhancing the Sensitivity of Colorimetric Aptasensor Through Cd2+‐Thymine Interactions in ssDNA Loops for Food Contaminant Detection

open access: yesFood Safety and Health, EarlyView.
This picture illustrates a novel aptamer‐based colorimetric assay, which demonstrates that high sensitivity, selectivity, and reliability for the rapid detection of cadmium ions (Cd2+) in water. Molecular dynamics (MD) simulations have revealed that the complexes are more stable, with Cd2+ binding more tightly to the thymine (T) within the aptamer loop.
Xuyan Li   +7 more
wiley   +1 more source

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