Results 81 to 90 of about 9,778 (229)

Future trends in Animal Breeding due to new genetic tecnologies

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
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Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein [PDF]

, 2014
Infections with human respiratory syncytial virus (HRSV) occur globally in all age groups and can have devastating consequences in young infants. We demonstrate that a vaccine based on the extracellular domain (SHe) of the small hydrophobic (SH) protein ...
Bert Schepens, Brian Gilbert, Cherrie AH, Connors M, Glezen WP, Kenny Roose, Koen Sedeyn, Liesbeth Vande Ginste, Lieselot Houspie, Marc Van Ranst, Michael Schotsaert, Mills JT, Nicholas JA, Nico Rooijen, Olmsted RA, Pedro Piedra, Sarah De Baets, Ventre K, Walter Fiers, Whitehead SS, Xavier Saelens   +20 more
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PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Estudio del transporte madre-hijo de anticuerpos antiestreptoquinasa

Revista Cubana de Investigaciones Biomédicas, 2002
Se estudió cómo se comporta el transporte de anticuerpos anti-estreptoquinasa entre la madre y el recién nacido y cuáles son los factores que influyen en este.
Lien López Matilla, Antonio González Griego, Alina Alerm González, Arturo Santiesteban Torres, Sonia Águila Setién, Amada Wanton, Edna Bancoul Moya, María Herminia Álvarez Díaz   +7 more
doaj  

Protective activity of the antilipopolysaccharide antibodies from human cord serum [PDF]

, 2006
We evaluated the ability of human maternal and cord serum antibodies to protect mice challenged with live Escherichia coli serotype O6:K2ac (E. coli O6). Mice received paired maternal or cord serum pools before a challenge with E. coli O6 to evaluate the
Arslanian, Christina, Friedlander-Del Nero, Dora Lisa, Massironi, Silvia Gomes, Nagao-Dias, Aparecida Tiemi, Pontes, Gerlandia Neres, Sales Carneiro-Sampaio, Magda Maria   +5 more
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Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Serosurvey for viruses associated with reproductive failure in newly introduced gilts and in multiparous sows in Belgian sow herds [PDF]

, 2009
A serosurvey for viruses associated with reproductive disorders was conducted in 25 conventional Belgian farms. Serum antibody titers for porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2), porcine parvovirus ...
Laitat, M, Lefebvre, David, Maes, Dominiek, Nauwynck, Hans, Van Driessche, E, Van Reeth, Kristien, Vangroenweghe, Frédéric   +6 more
core   +1 more source

Effect of maternal Schistosoma mansoni infection and praziquantel treatment during pregnancy on Schistosoma mansoni infection and immune responsiveness among offspring at age five years. [PDF]

, 2013
INTRODUCTION: Offspring of Schistosoma mansoni-infected women in schistosomiasis-endemic areas may be sensitised in-utero. This may influence their immune responsiveness to schistosome infection and schistosomiasis-associated morbidity.
AG Ross, Alison M. Elliott, AM Elliott, AM Elliott, CL King, CW Naus, David W. Dunne, DW Dunne, EJ Pearce, Emily L. Webb, FG Abath, Frances M. Jones, HE Allen, HM Coutinho, HM Coutinho, I Malhotra, I Malhotra, I Malhotra, J Utzinger, J. Russell Stothard, JC Sousa-Figueiredo, JF Friedman, JR Stothard, JR Verani, JT Scott, K Broen, LFA Oliveira, M Booth, M Brown, M Hesse, MA Montesano, MA Montesano, MI Araujo, MS Wilson, Patrice A. Mawa, Peter Naniima, R Correa-Oliveira, R Tweyongyere, R Tweyongyere, R Tweyongyere, RE Weir, RM Maizels, RM Maizels, Robert Tweyongyere, S Joseph, S Joseph, S Wilson, SE Odogwu, SJ Jenkins, Stephen Cose   +49 more
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A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Causes and consequences of variation in nestling immune function [PDF]

, 2007
Defence against pathogens is a vital need of all living organisms that has led to the evolution of complex immune mechanisms. However, although immunocompetence the ability to resist pathogens and control infection has in recent decades become a ...
Pitala, Natalia
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