Results 101 to 110 of about 334,743 (321)
Advanced Science, EarlyView.This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang +5 more
wiley +1 more source
Advanced Science, EarlyView.Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin +3 more
wiley +1 more source
BMC Infectious DiseasesBackground Previous evidence had suggested age and sex affect the reporting rate of adverse events following immunization (AEFI), but with little exploration of potential their non-linear and interaction effects on AEFIs.
Fuxing Chen +6 more
doaj +1 more source
Epidemic spreading with immunization on bipartite networks [PDF]
arXiv, 2011 Bipartite networks are composed of two types of nodes and there are no links between nodes of the same type. Thus the study of epidemic spread and control on such networks is relevant to sexually transmitted diseases (STDs). When entire populations of two types cannot be immunized and the effect of immunization is not perfect, we have to consider the ...
arxiv
Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
wiley +1 more source
Artificial Immune Systems Tutorial [PDF]
arXiv, 2008 The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self-cells or non-self cells. It does this with the help of a distributed task force that has the intelligence to take action from a local and also a global perspective ...
arxiv
Active Immunization against Poliomyelitis. A Comparative Study [PDF]
, 1936 Stefanie D. Krämer +2 more
openalex +1 more source
Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine
Advanced Science, EarlyView.A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li +14 more
wiley +1 more source
Infection-acquired versus vaccine-acquired immunity in an SIRWS model [PDF]
arXiv, 2017 Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity. In some disease systems, the process of waning immunity can be non-linear, involving a complex relationship between the duration of immunity and subsequent boosting of immunity through ...
arxiv
ACTIVE IMMUNIZATION OF NURSES AGAINST DIPHTHERIA IN A CHILDREN'S HOSPITAL [PDF]
, 1922 Jean V. Cooke
openalex +1 more source