Results 31 to 40 of about 430,211 (318)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Methodological quality of systematic intervention reviews on vaccination
Systematic ReviewsBackground Systematic reviews (SRs) are pivotal in vaccination recommendation development. However, the reliability of their findings relies on methodological rigor.
Antonia Pilic +11 more
doaj +1 more source
Infectious Diseases of Poverty, 2019 Background Mother to child transmission of hepatitis B virus (HBV) remains the most common form of HBV infection in China. Prevention of HBV vertical transmission involves timely administration of the complete hepatitis B vaccine (HepB) series and ...
Hui Zheng +9 more
doaj +1 more source
Immune Dysregulation in Immune Thrombocytopenia [PDF]
Seminars in Hematology, 2013 Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Karina, Yazdanbakhsh +2 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Neuroscience and Behavioral Physiology, 2020 This review presents data on changes in measures of innate and adaptive immunity associated with the state of sleep. The effects of restricted and prolonged sleep duration on measures of morbidity, mortality, and susceptibility to infectious diseases and the effects of vaccination are discussed.
openaire +3 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
A Practical Guide to Full Value of Vaccine Assessments
VaccinesArticulating the wide range of health, social and economic benefits that vaccines offer may help to overcome obstacles in the vaccine development pipeline.
Caroline Trotter +14 more
doaj +1 more source
Changes in the epidemiology of hepatitis A in three socio-economic regions of China, 1990–2017
Infectious Diseases of Poverty, 2019 Background Hepatitis A (HepA) vaccination and economic transitions can change the epidemiology of HepA. China’s Gross Domestic Product (GDP) per capita was known to be inversely associated with the incidence of HepA, but a deeper understanding of the ...
Xiao-Jin Sun +6 more
doaj +1 more source