Results 41 to 50 of about 241,504 (343)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Safety of an inactivated enterovirus 71 vaccine administered concurrently with other vaccines among infants aged 6–11 months: An observational study using active surveillance

Human Vaccines & Immunotherapeutics
Vaccine co-administration can efficiently increase vaccination uptake and timely immunization. This study aimed to evaluate the safety of the enterovirus 71 (EV71) vaccine administered alone or concurrently with other vaccines in infants 6–11 months.
Linlin Wu, Yu Zhang, Jiechen Liu, Zhuoying Huang, Huiyong Shao, Xiaoying Ma, Xiaodong Sun   +6 more
doaj   +1 more source

Factors Associated with Immunization Opinion Leadership among Men Who Have Sex with Men in Los Angeles, California [PDF]

, 2018
We sought to identify the characteristics of men who have sex with men (MSM) who are opinion leaders on immunization issues and to identify potential opportunities to leverage their influence for vaccine promotion within MSM communities.
Bednarczyk, Robert, Fenimore, Vincent L., Frew, Paula M., Goldbeck, Cameron, Himmelstein, Rebecca, Holloway, Ian W., Lutz, Chelsea S., Randall, Laura, Tan, Diane, Wu, Elizabeth   +9 more
core   +3 more sources

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups

Advanced Materials, EarlyView.
An acid‐responsive polymeric micelle system based of aliphatic poly(carbonate)s with benzyl ketal side chains is designed for targeted immunodrug delivery. It can disassemble in endosomal environments, enabling site‐specific immunoactivation and enhanced biodegradability.
Adrian V. Hauck, Michael Fichter, Laura J. Rosenberger, Jannis Willig, Alexander Fuchs, Felicia Schön, Paul Schneider, Carolina Medina‐Montano, Taufiq Ahmad, Jessica Erlenbusch, Pol Besenius, Leonard Kaps, Matthias Bros, Stephan Grabbe, Volker Mailänder, Jürgen Groll, Lutz Nuhn   +16 more
wiley   +1 more source

Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015

BMC Infectious Diseases, 2020
Background Monitoring hepatitis B surveillance data is important for evaluating progress towards global hepatitis B elimination goals. Accurate classification of acute and chronic hepatitis infections is essential for assessing program effectiveness ...
Hui Zheng, Alexander J. Millman, Jeanette J. Rainey, Fuzhen Wang, Rui Zhang, Hong Chen, Zundong Yin, Huaqing Wang, Guomin Zhang   +8 more
doaj   +1 more source

Impact of periodic intensification of routine immunization within an armed conflict setting and COVID-19 outbreak in Cameroon in 2020

Conflict and Health, 2022
Introduction Cameroon’s Southwest Region (SW) has been hit by an armed conflict for over half a decade now, negatively affecting the region’s routine immunization and disease surveillance activities.
Andreas Ateke Njoh, Yauba Saidu, Hassan Ben Bachir, Shalom Tchokfe Ndoula, Eric Mboke, Raoul Nembot, Afizu Chrakoh Tambasho, Messang Blandine Abizou, Judith Seungue, Clarence Mbanga, Victor Njie Mbome   +10 more
doaj   +1 more source

Immunogenicity and safety of concomitant administration of the chinese inactivated poliovirus vaccine with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine in children: A multicenter, randomized, non-inferiority, controlled trial

Frontiers in Immunology, 2022
Key pointConsidering that vaccination with the sIPV and DTaP overlap at the ages of 3 and 4 months in China, to reduce the burden of treatment on parents and increase vaccination coverage rates, we designed a postmarket clinical study of co ...
Xiang Sun, Yan Xu, Fenyang Tang, Yanhui Xiao, Zhiguo Wang, Binbing Wang, Xiaoping Zhu, Xiaoming Yang, Haiping Chen   +8 more
doaj   +1 more source

Vaccines: Propaganda and Practice [PDF]

, 2008
Vaccines are a cost effective, time tested means of reducing morbidity and mortality. As more and more new vaccines are introduced and more diseases come under the purview of ‘vaccination net’, the routine immunization program is sidelined.\ud This is ...
Baliga, Shantharam B, Baliga, Shrikala
core   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Acceptance and willingness to pay for DTaP-HBV-IPV-Hib hexavalent vaccine among parents: A cross-sectional survey in China

Human Vaccines & Immunotherapeutics
DTaP-HBV-IPV-Hib hexavalent vaccine has been used in high-income countries for many years to prevent diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive Haemophilus influenzae type b disease.
Aodi Huang, Xia Xu, Lin Tang, Lifang Huang, Jun Li, Xue Zhang, Jiajie Liu, Yang Zhou, Bingling Zhang, Lei Wang, Qian Zhang, Zemei Zhou, Yu Wang, Xiaoqi Wang, Qianqian Liu, Siyu Liu, Zundong Yin, Fuzhen Wang   +17 more
doaj   +1 more source