Results 91 to 100 of about 4,533 (248)
Sex differences in immunocompetence differ between two Peromyscus species
, 1997 Males generally exhibit reduced immunocompetence and greater susceptibility to disease than females. The explanations for why males may be more susceptible to disease than females fall into two categories: 1) the proximate mechanisms mediating immunity,
R. J. Nelson, S. L. Klein
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Advanced Science, EarlyView.Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source
Immunocompetence and the Hygiene Hypothesis datasets
, 2010 Data for the Immunocompetence and the Hygiene Hypothesis project were collected in Kilimanjaro, Tanzania in 2010. For additional information, please see: https://doi.org/10.1371/journal.pone.0037406; 10.1098/rspb.2013.1359; DOI: 10.1002/ajhb.22729; 10 ...
Wander, Katherine
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Modeling Development Immunocompetence and Immunoresponsiveness to Challenge in Chicks
, 2007 The purpose of this study was 2-fold: 1) to develop a deterministic model that describes the development of immunocompetence and the kinetics of immunoresponsiveness to a pathogenic challenge in chicks and 2) to use this model to illustrate the ...
van der Waaij, E.H. +3 more
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F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
Selection for general immunocompetence in chickens [PDF]
, 1990 This experiment was designed to study selection for general immunocompetence by using a selection index. A total of 460 chicks from 20 sire families (randomly divided into 2 replicates of 10 sire families each) of a random breeding egglaying chicken line
Cheng, S., Lamont, Susan
core
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Fatal cryptococcal meningitis in an immunocompetent patient
Journal of Infection in Developing CountriesIntroduction: Cryptococcal meningitis (CM) typically affects immunocompromised individuals and are commonly caused by Cryptococcus neoformans. Case Report: We present CM case involving an immunocompetent male due to Cryptococcus gattii molecular type ...
Minoosh Shabani +7 more
doaj +1 more source