Results 181 to 190 of about 224,518 (341)

ANAESTHESIA AND IMMUNOCOMPETENCE

British Journal of Anaesthesia, 1976
G C, Moudgil, A G, Wade
openaire   +2 more sources

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

Nature, 2017
R. Lis, Charles C. Karrasch, Michael G. Poulos, Balvir Kunar, D. Redmond, J. G. B. Durán, Chaitanya R. Badwe, William Schachterle, Michael Ginsberg, J. Xiang, A. R. Tabrizi, K. Shido, Z. Rosenwaks, O. Elemento, N. Speck, J. Butler, J. Scandura, S. Rafii   +17 more
semanticscholar   +1 more source

Plasma calprotectin to assess susceptibility to bloodstream infections during paediatric acute lymphoblastic leukaemia induction treatment

British Journal of Haematology, EarlyView.
Summary Chemotherapy‐induced neutropenia, monitored by peripheral blood absolute neutrophil count (ANC), increases the risk of bloodstream infections (BSIs). However, ANC may not reflect the total neutrophil population, as it omits neutrophils at extravascular sites.
Johanna Vævest Nymann Eriksen, Silvia de Pietri, Mathias Rathe, Henrik Hasle, Christian Enevold, Claus H. Nielsen, Kjeld Schmigelow, Claus Moser, Klaus Müller, Sarah Weischendorff   +9 more
wiley   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Clinical Microbiology Reviews, 2014
T. Lion
semanticscholar   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Detection of human antibody responses to tick-borne Neoehrlichia mikurensis. [PDF]

Med Microbiol Immunol
Alsalihi R, Andersson K, Aranburu A, Lingblom C, Wass L, Lewerin C, Edvinsson M, Mårtensson A, Nilsson K, Skoog E, Lundell AC, Bergström B, Grankvist A, Wennerås C.   +13 more
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Epidemiology of Multiple Herpes Viremia in Previously Immunocompetent Patients With Septic Shock

Clinical Infectious Diseases, 2017
D. Ong, M. Bonten, C. Spitoni, F. V. Verduyn Lunel, J. Frencken, J. Horn, M. Schultz, T. van der Poll, P. K. Klein Klouwenberg, O. Cremer   +9 more
semanticscholar   +1 more source