Results 281 to 290 of about 224,518 (341)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, Volume 13, Issue 16, 18 March 2026.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

A Case Report on Disseminated <i>Mycobacterium avium</i> Complex Infection in an Otherwise Healthy Individual-A Diagnostic Challenge. [PDF]

Clin Case Rep
Hridoy AB, Newaz S, Ahmed M, Tina JA, Sarker S, Tabassum A, Al-Aziz MZ, Amin MR.   +7 more
europepmc   +1 more source

HHV-6-induced hydrocephalus with ventricular septa formation in an immunocompetent adult: illustrative case. [PDF]

J Neurosurg Case Lessons
Paul U, Mietus CJ, Owusu-Adjei B, Sorour O, Karandikar PV, Johnson MD.   +5 more
europepmc   +1 more source

Coccidioidomycosis Masquerading as Malignancy: A Case of Mediastinal Mass and Pericardial Effusion in an Immunocompetent Jamaican Male. [PDF]

Case Rep Infect Dis
Governor SB, Zaidi M, Nepali P, Grigorova Y, Baissari A, Toussaint R, Dabaghyan M, Melendez-Garcia A, Jammal R.   +8 more
europepmc   +1 more source

A Lethal Case of Cryptococcal Meningitis in an Apparently Immunocompetent Patient: A Case Report Highlighting Diagnostic Pitfalls and Therapeutic Challenges. [PDF]

Cureus
Leong WH, Gan WF, Tan KT.
europepmc   +1 more source

Acute transverse myelitis in an immunocompetent patient: syphilis and cytomegalovirus-a case report. [PDF]

AME Case Rep
Tang ECW, Pearson D, Warner G.
europepmc   +1 more source