Results 131 to 140 of about 1,620,419 (294)
Advanced Science, EarlyView.A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan +12 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyObjectivesSerum albumin strongly influences isavuconazole pharmacokinetics due to its high plasma protein binding. Hypoalbuminemia, common in critically ill and immunocompromised patients, may cause subtherapeutic concentrations with standard ...
Xiao-Chen Wei +3 more
doaj +1 more source
Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming
Advanced Science, EarlyView.Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva +18 more
wiley +1 more source
Acquired tufted angioblastoma in an immunocompetent patient
, 2016 Acquired tufted angioma (ATA) is a rare benign vascular tumor, most commonly localized to skin and subcutaneous tissues. Its name is based on its specific histologic pattern, characterized by lobular arrangement of densely cellular capillaries, grouped ...
Somenath Sarkar +3 more
core +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Advanced Science, EarlyView.The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru +15 more
wiley +1 more source
Herpes Simplex Esophagitis in an Immunocompetent Adult
CureusHerpes simplex esophagitis (HSE) caused by herpes simplex virus (HSV) infection is a well-recognized opportunistic infection in an immunocompromised host. HSE in immunocompetent patients is an uncommon clinical event; however, when it does occur, it is generally a self-limiting condition. This case involves an immunocompetent 19-year-old female patient
Bresler, Richard M +4 more
openaire +2 more sources
, 2012 INTRODUCTION Fulminant myocarditis, especially those caused by the Ebstein-Barr Virus (EBV) is a rare disease (1). For the first time, we describe a case of fulminant myocarditis caused by EBV in a young, immunocompetent adult, co-infected with ...
• A Horovitz, I El Zein, R Valentino, H Medhaoui, J Inamo
core
, 2014 Cat-scratch disease (CSD) is the most frequent presentation of Bartonella henselae infection. It has a worldwide distribution and is associated with a previous history of scratch or bite from a cat or dog.
Oteo, José A. +5 more
core +1 more source
Animal Research and One Health, EarlyView.Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito +15 more
wiley +1 more source