Results 121 to 130 of about 238,930 (305)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Safety and immunogenicity of a modified mRNA-lipid nanoparticle vaccine candidate against COVID-19: Results from a phase 1, dose-escalation study

Human Vaccines & Immunotherapeutics
This phase 1, open-label, dose-escalation, multi-center study (NCT05477186) assessed the safety and immunogenicity of a booster dose of an mRNA COVID-19 vaccine (CV0501) encoding the SARS-CoV-2 Omicron BA.1 spike protein.
Brandon J. Essink, Craig Shapiro, Marie Grace Dawn Isidro, Paul Bradley, Antoinette Pragalos, Mark Bloch, Joel Santiaguel, Melchor Victor Frias, Spiros Miyakis, Margarida Alves de Mesquita, Stefano Berrè, Charlotte Servais, Natasha Waugh, Claudia Hoffmann, Emna Baba, Oliver Schönborn-Kellenberger, Olaf-Oliver Wolz, Sven D. Koch, Tapiwa Ganyani, Philippe Boutet, Philipp Mann, Stefan O. Mueller, Roshan Ramanathan, Martin Robert Gaudinski, Nicolas Vanhoutte   +24 more
doaj   +1 more source

immunogen

, 2014
Citation: 'immunogen' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.I02981 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Ex vivo immunogenicity analysis.

, 2016
The Epibase® assay is a human PBMC T-cell immunogenicity assay used to assess “immunogenicity risk”. In this assay, PBMC samples from 202 normal donors were used to screen the T-cell immunogenicity of a modified Arthrobacter globiformis uricase candidate
James C. Geoghegan (214152), Ryan Bean (3597401), Vidyashankara Iyer (3597395), Jeffrey N. Miner (2475367), Herren Wu (166537), Jane Osbourn (3597407), Steven Coats (3597383), Dongmei Zhou (786550), David A. Owen (3083265), Mark Berge (3597410), Clynn Wilker (3597398), Anna Zacco (2004736), Flaviu Gruia (1778275), Benoy Chacko (3597389), Frank Bartnik (3597392), David M. Wilson (7496), Chris Ward (67965), Michaela Wendeler (1857736), Hui Feng (174331), Andrew C. Nyborg (3597386), Varnika Roy (2073448), Chi Y. Wu (3597380), Manuel Baca (1857742), Simone Nicholson (3597404), Lutz Jermutus (608646), Luba Grinberg (1857745), Ellen O’Connor (3597413), Susan Wilson (134263)   +27 more
core   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Allergy, Asthma & Clinical Immunology, 2017
I. J. Pouliquen, P. Howarth, D. Austin, G. Gunn, E. Meyer, R. G. Price, E. Bradford   +6 more
doaj   +1 more source

A worldwide overview for hexavalent vaccines and a glimpse into Turkiye’s perspective

Human Vaccines & Immunotherapeutics
The surge in recommended vaccinations for child’s has spurred the development of combination vaccines, notably hexavalent vaccines, which provide multiple immunizations in a single dose.
Metehan Özen, Emin Ünüvar, Abdurrahman Yıldırım, Hakkı Akman, Süleyman Mevlitoğlu, Tamer Pehlivan   +5 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Development of mRNA rabies vaccines

Human Vaccines & Immunotherapeutics
Rabies, primarily transmitted to humans by dogs (accounting for 99% of cases). Once rabies occurs, its mortality rate is approximately 100%. Post-exposure prophylaxis (PEP) is critical for preventing the onset of rabies after exposure to rabid animals ...
Zixin Fang, Pengcheng Yu, Wuyang Zhu
doaj   +1 more source

Predicted immunogenicity.

, 2013
Distribution of Epivax Scores for human and murine heavy chain sequences of 500 randomly picked sequences from the Abysis data set are shown. Low Scores indicate a lower risk of immunogenicity.
Daniel Seeliger (254957)
core   +1 more source