Results 81 to 90 of about 13,987,796 (252)

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Success story of prevention and management of Rh(D)-isoimmunized pregnancy, foetus and newborn [Part I]

Current Medicine Research and Practice, 2013
Management of an Rh(D)-negative alloimmunized pregnant woman has been a major challenge in obstetrics ever since Landsteiner reported the association of this condition with haemolytic disease of the foetus and newborn. In the past five decades through an
Geeta Mediratta, Nandita Dimri, S K Bhandari   +2 more
doaj  

Fibrin and D-dimer bind to monomeric GPVI

Blood Advances, 2017
: Fibrin has recently been shown to activate platelets through the immunoglobulin receptor glycoprotein VI (GPVI). In the present study, we show that spreading of human platelets on fibrin is abolished in patients deficient in GPVI, confirming that ...
Marie-Blanche Onselaer, Alexander T. Hardy, Clare Wilson, Ximena Sanchez, Amir K. Babar, Jeanette L.C. Miller, Callum N. Watson, Stephanie K. Watson, Arkadiusz Bonna, Helen Philippou, Andrew B. Herr, Diego Mezzano, Robert A.S. Ariëns, Steve P. Watson   +13 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Point-of-care determination of the frequency of Rhesus(D)-negative blood types and the uptake of anti(D) immunoglobulin among Rh(D)-negative women in Dadu district, Sindh, Pakistan.

PLOS Global Public Health
Rhesus (Rh) disease remains a serious problem in low- and middle-income countries. Rh disease prevention requires early identification and prophylactic treatment of Rh(D)-negative women.
Lisa G Pell, Shabina Ariff, Gul Nawaz Khan, Hana Dampf, Shah Muhammad Jokhio, Alvin Zipursky, Jillian M Baker, Sidrah Nausheen, Sajid Soofi, Shaun K Morris   +9 more
doaj   +1 more source

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Frontiers in Immunology
Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo, Kouji Hirota, Kunihiro Ohta   +2 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Immunoglobulin Secretion in Chronic Fatigue Syndrome

, 2014
Objectives: Immunoglobulins (Ig) are secreted by activated B cells in response to invading pathogens. The subclasses or isotypes of immunoglobulins are IgA, IgD, IgE, IgG and IgM each of which possesses a specific effector function.
Staines, Don, Hardcastle, Sharni Lee, Marshall-Gradisnik, Sonya, Nguyen, Thao, Ramos, Sandra Bahia, Johnston, Samantha, Brenu, Ekua, Huth, Teilah Kathryn, Fuller, Kirsty   +8 more
core