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The discovery of immunoglobulin E
Immunology Letters, 2016The discovery of immunoglobulin E (IgE) was a breakthrough in the field of allergy and immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. The first clue to the existence of a substance responsible for hypersensitivity
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Immunoglobulin E in aqueous humour
Experimental Eye Research, 1985The level of immunoglobulin E (IgE) was determined in the aqueous humour (AH) and serum by particle counting immunoassay (limit of sensitivity: 0.2 IU ml-1). This level in the AH was below 0.75 IU ml-1 in case of senile cataract (n = 22) and ranged from this assumed normal value to 550 IU ml-1 in case of uveitis (n = 37), Fuchs' cyclitis (n = 11 ...
C.G.M. Magnusson +5 more
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Role of immunoglobulin E and immunoglobulin E receptors in bronchial asthma
Journal of Allergy and Clinical Immunology, 1981The molecular and cellular events involved in the immediate hypersensitivity response, illustrated in Fig. 1, have received increasing attention in recent yeass. l* 2 Not only is this response the basis for allergic diseases but also it provides a relatively simple model for immunologic activation of specific cells, which may be applicable to other ...
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A model of the Fc of immunoglobulin E
Molecular Immunology, 1986A model of the Fc of human IgE was constructed using the known three-dimensional structure of IgG Fc. On the basis of amino acid sequence homology, the CE2, CE3 and CE4 domains were modelled after CG3, CG2 and CG3, respectively. The mode of association of the CG2 and of the CG3 pairs of domains was assumed for the CE3 and the CE4 pairs, respectively ...
David R. Davies, Eduardo A. Padlan
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Immunoglobulin E in Renal Disease
Nephron, 1976Samples of renal tissue from 373 patients were examined for the presence of immunoglobulin E (IgE) by immunofluorescent techniques. Only trace to ++ amounts ( on a scale of ++++) were found in 20 patients: 4/9 with post-streptococcal acute glomerulonephritis (GN), 5/30 with GN associated with systemic lupus erythematosus, 3/20 with membranous GN, 1/4 ...
Malcolm R. Robertson +3 more
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Immunoglobulin E and its regulators
Current Opinion in Allergy and Clinical Immunology, 2001Novel paradigms are emerging in the field of IgE regulation. Gene-environment interactions are increasingly considered to be major determinants of the type and amplitude of allergen-induced antibody responses. At the molecular level, the mechanistic connection between transcription and switching has been strengthened by the recent discovery that class ...
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Immunoglobulin E in Nigerian Onchocerciasis
The American Journal of Tropical Medicine and Hygiene, 1977Total serum IgE was measured by radioimmunoassay in 58 adult Nigerian patients with untreated onchocerciasis. Levels in excess of 244.9 IU/ml, the mean level of the healthy Nigerian control subjects tested, were found in 86% of the patients. The levels were comparable to IgE levels found in 15 atopic Nigerian patients from the same residential area ...
D. C. Heiner +2 more
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Phosphorylation of the receptor for immunoglobulin E
Biochemistry, 1982Specific immune precipitation of immunoglobulin E(IgE)-receptor complexes from detergent extracts of 32P-labeled rat basophilic leukemia cells yielded a phosphoprotein of Mr approximately 35,000 on gel electrophoresis in sodium dodecyl sulfate.
Davis Cl, Metzger H, Fewtrell C
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Immunoglobulin E as a Biomarker in Asthma
Immunology and Allergy Clinics of North America, 2018Asthma is a chronic disease that affects children and adults with significant morbidity and mortality. It is multifactorial, with genetic and environmental factors affecting the overall course of the disease. Both specific and total immunoglobulin (Ig)E can be used in specific phenotypes such as allergic asthma.
Nikita Raje +2 more
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1985
Publisher Summary This chapter provides an overview of immunoglobulin E (IgE). IgE is the least component of the immunoglobulin family in humans and experimental animals. The concentration of the immunoglobulin in normal human serum is in the order of 100 to 200 ng/ml. However, IgE antibodies have unique biologic activities.
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Publisher Summary This chapter provides an overview of immunoglobulin E (IgE). IgE is the least component of the immunoglobulin family in humans and experimental animals. The concentration of the immunoglobulin in normal human serum is in the order of 100 to 200 ng/ml. However, IgE antibodies have unique biologic activities.
openaire +3 more sources