The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. [PDF]
, 1991 A family of chimeric immunoglobulins (Igs) bearing the murine variable region directed against the hapten dansyl linked to human IgG1, -2, -3, and -4 has been characterized with respect to binding to the human high affinity Fc gamma receptor, Fc gamma RI.
Canfield, SM, Morrison, SL
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Blood preparations of humans and animals in terms of their quality, efficacy and safety
Биопрепараты: Профилактика, диагностика, лечение, 2018 The problems of quality and safety products derived from human blood plasma and hyperimmune animal sera as well as recombinant blood products resolved strict government regulation of their production processes.
M. V. Supotnitsky +10 more
doaj
Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]
, 1993 Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
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Proteolysis of defensive proteins in peritonitis exudate [PDF]
, 1991 Assfalg-Machleidt, Irmgard +4 more
core +1 more source
Limited proteolysis of human and rabbit immunoglobulins by snake venoms produces Fab-like fragments.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1992 Rabbit and, to a lesser extent, human immunoglobulins (IgGs) are cleaved by snake venoms. The snake venom proteases active on IgGs release fragments which behave on SDS-PAGE like Fab units similar to those released by the thiol-activated enzymes. However, in contrast to the cysteine proteases, the activity of snake venom proteases on IgGs is not only ...
M T, Assakura, F R, Mandelbaum
openaire +1 more source
Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1977 Parenteral administration of antiencephalytic gamma-globulin and of the Fab-fragments, extracted from it, to rabbits stimulated the formation of specific antibodies. The maximal blood serum specific antibody level in rabbits reimmunized with Fab-fragments was much lower than that following the reimmunization of rabbits with gamma-globulin.
P S, Barban +3 more
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Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans [PDF]
, 2015 Bruce P Burnett, Victoria S Jasion
core +1 more source
Complete and Rapid NMR Characterization of Therapeutic Monoclonal Antibodies via Differential Labeling of Fab Fragments in <i>Escherichia coli</i>. [PDF]
Anal ChemGagné D, Aubin Y.
europepmc +1 more source