Results 61 to 70 of about 22,797 (166)

Model‐Informed Development of a Subcutaneous Formulation of Tislelizumab: Phase 1 Pharmacokinetics in Patients With Cancer

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT Although tislelizumab is approved across multiple malignancies and dosing schedules, intravenous administration imposes logistical burdens. A subcutaneous formulation may improve convenience and reduce resource demands if comparable exposure is achieved. This study evaluated the pharmacokinetics, bioavailability, and injection‐site performance
Xiangyu Liu, Ye Guan, Yixi Liu, Tian Yu, Ramil Abdrashitov, Ziru Niu, Xiao Lin, Xiaohan Ye, Yutong Wang, Srikumar Sahasranaman, William D. Hanley, Nageshwar Budha   +11 more
wiley   +1 more source

Head and neck immunoglobulin G4 related disease: systematic review

, 2018
Immunoglobulin G4 related disease is a recently described systemic syndrome. The head and neck region is the second most common site for presentation after the pancreas.
Del Piero G., Gardenal N., Tirelli G., Quatela E., Gatto A.   +4 more
core   +1 more source

Erdheim–Chester Disease Involving the Biliary System and Mimicking Immunoglobulin G4-Related Disease: A Case Report

, 2023
First described in 1930 as a lipoid granulomatosis, Erdheim-Chester disease (ECD) is a rare histiocytosis encompassing a group of disorders caused by overproduction of histiocytes, a subtype of white blood cells. This disease most commonly involves the
Yeo Eun Kim, Yong Eun Chung, Hyuk Gi Hong, June Park   +3 more
core   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, Volume 13, Issue 33, 15 June 2026.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

A case of massive hemoptysis caused by immunoglobulin G4-related respiratory disease in adults: case report and review of literature

Frontiers in Immunology
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated chronic fibro-inflammatory condition, that can involve multiple systems. Immunoglobulin G4-related respiratory disease (IgG4-RRD) is relatively rare, with non-specific clinical symptoms ...
Chun-xia Mei, Guo-long Yue, Xia Feng, Hai-qiao Wu, Jiong Li   +4 more
doaj   +1 more source

Immunoglobulin G4 hypophysitis in a 63-year-old woman with no autoimmune history: a case report

Journal of Medical Case Reports, 2021
Background Immunoglobulin-G4-related hypophysitis is a rare inflammatory disease that can present as a tumefactive pituitary lesion mimicking hypophyseal neoplasms such as pituitary adenoma or craniopharyngioma.
Zachary C. Gersey, Kenan R. Rajjoub, Thomas M. Pearce, Scott A. Segel, Paul A. Gardner, Carl H. Snyderman, Eric W. Wang, Georgios A. Zenonos   +7 more
doaj   +1 more source

Immunoglobulin G4 related mastitis: A case report

, 2020
Immunoglobulin (Ig)G4-related sclerosing disease is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and ...
Erdem, Ergün, Atigan, A., Demirkan, Neşe, Utku OZGEN, Ergun ERDEM, Ozgen, U., Ayhan ATIGAN, Nese DEMIRKAN   +7 more
core   +1 more source

Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report. [PDF]

Front Immunol
Castleman disease (CD) and immunoglobulin G4-related disease (IgG4-RD) are rare systemic immune-mediated disorders that share overlapping clinical features, posing significant challenges in differential diagnosis.
Li N, Xu L, Liu X, Wu P, Liu J, Zeng J.
europepmc   +2 more sources

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, Volume 16, Issue 6, Page 561-571, June 2026.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Immunoglobulin G4-related Lung Disease: A Disease with Many Different Faces [PDF]

, 2013
Immunoglobulin (Ig) G4-related lung disease is a fibroinflammatory entity that presents in protean ways. Diagnostically, IgG4-related lung disease requires a high clinical index of suspicion complemented by elevated serum IgG4 levels and/or biopsy that ...
André Mattman, Pearce G Wilcox, Don D Sin, Joanne L Wright, Philip Hui   +4 more
core   +1 more source