Results 61 to 70 of about 1,441,564 (292)
Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States
Advanced Science, EarlyView.Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton +13 more
wiley +1 more source
The immunoglobulin heavy chain locus in the reptile Anolis carolinensis
Molecular Immunology, 2009 We describe the entire immunoglobulin heavy chain (IgH) locus from the reptile Anolis carolinensis. The heavy chain constant (C(H)) region includes C mu, C delta and C upsilon genes. This is the first description of a C upsilon gene in the reptilian class. Variable (V(H)), diversity (D(H)) and joining (J(H)) genes are located 5' from the constant (C(H))
Magadán-Mompó, S. (Susana) +2 more
openaire +4 more sources
Immunoglobulin light chains in uremia [PDF]
, 2003 Immunoglobulin light chains in uremia.BackgroundImmunoglobulin light chains (IgLCs) are produced by B cells, slightly in excess of immunoglobulin heavy chains, and therefore are present in the serum of healthy adults in free form at low concentrations ...
Gerald Cohen, Cohen, Gerald
core +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Frontiers in ImmunologyPoultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo +2 more
doaj +1 more source
Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]
, 1988 The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas +6 more
core +1 more source
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Frontiers in ImmunologyThe B cell repertoire contains the recombined sequences that encode the entire antibody repertoire of an individual. The repertoire is made from three antigenic binding chains, namely the immunoglobulin heavy chain (IGH) and two immunoglobulin light ...
Aya K. H. Mahdy +7 more
doaj +1 more source
IMMUNOGLOBULIN E ROLE IN PARASITIC DISEASES: AN OVERVIEW [PDF]
Journal of the Egyptian Society of ParasitologyImmunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that is found only in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, the ε chain containing four Igs-
SARYA HAWAM, OSAMA ZAKI, TOSSON MORSY
doaj +1 more source
Characterization of Tear Immunoglobulins in a Small-Cohort of Keratoconus Patients
Scientific Reports, 2020 Keratoconus (KC) is classically considered a non-inflammatory condition caused by central corneal thinning that leads to astigmatism and reduced visual acuity.
Tina B. McKay +4 more
doaj +1 more source