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Immunoglobulin light chain amyloidosis
memo - Magazine of European Medical Oncology, 2021 Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains.
H. Agis, M. Krauth
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Immunoglobulin light chain amyloidosis and the kidney [PDF]
Kidney International, 2002 Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Martha Q. Lacy +2 more
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Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case
Saudi Journal of Kidney Diseases and Transplantation, 2021 The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari +5 more
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Diagnosing a Challenging Case of Primary Amyloidosis using Capillary Electrophoresis [PDF]
National Journal of Laboratory Medicine, 2021 Amyloid Light chain (AL) amyloidosis is characterised by deposition of intact free light chains or their fragments in extracellular space. Here, authors describe the journey of a diagnostically challenging patient who presented with features of ...
rashmi verma +4 more
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Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]
, 2021 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv +1 more source
Renal Failure, 2023 Background Crystal-storing histiocytosis (CSH), light chain proximal tubulopathy (LCPT), and light chain crystalline podocytopathy (LCCP) are rare complications of multiple myeloma (MM) or monoclonal gammopathy of renal significance, and their diagnoses ...
Li Zhu +9 more
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Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (Al). [PDF]
PLoS ONE, 2012 Renal involvement is a frequent consequence of plasma cell dyscrasias. The most common entities are light chain amyloidosis, monoclonal immunoglobulin deposition disease and myeloma cast nephropathy.
Marina Ramirez-Alvarado +7 more
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PROPERTIES OF HALVES OF IMMUNOGLOBULIN LIGHT CHAINS [PDF]
Proceedings of the National Academy of Sciences, 1969 Light polypeptide chains from both normal human γG immunoglobulin and Bence-Jones proteins can be cleaved into halves by limited proteolysis with trypsin, pepsin, or papain. The fragments were obtained in yields of up to 22 per cent, had molecular weights of 10,000 to 11,000, and were shown by amino acid analysis and antigenic analysis to correspond to
Per A. Peterson +2 more
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Surgical and Experimental Pathology, 2023 Background Immunofluorescence studies on frozen sections are an essential component in the evaluation of renal biopsies. The basic panel in most centres constitutes IgG, IgA, IgM, C3c, C1q, Kappa and Lambda light chain antibody testing.
Shilpi Thakur, Balan Louis Gaspar
doaj +1 more source
Immunoglobulin light chains in uremia [PDF]
Kidney International, 2003 Immunoglobulin light chains (IgLCs) are produced by B cells, slightly in excess of immunoglobulin heavy chains, and therefore are present in the serum of healthy adults in free form at low concentrations. Both the kappa and lambda form of these polyclonal IgLCs are mainly metabolized by the kidney and appear under normal conditions only in small ...
openaire +2 more sources