Results 71 to 80 of about 461,541 (350)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Collective Light Emission of a Finite Size Atomic Chain [PDF]

EPL 100, 24002 (2012), 2012
Radiative properties of collective electronic states in a one dimensional atomic chain are investigated. Radiative corrections are included with emphasize put on the effect of the chain size through the dependence on both the number of atoms and the lattice constant. The damping rates of collective states are calculated in considering radiative effects
arxiv   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Lack of evidence for a substantial rate of templated mutagenesis in B cell diversification [PDF]

arXiv, 2020
B cell receptor sequences diversify through mutations introduced by purpose-built cellular machinery. A recent paper has concluded that a "templated mutagenesis" process is a major contributor to somatic hypermutation, and therefore immunoglobulin diversification, in mice and humans.
arxiv  

Recommendations for use of free light chain assay in monoclonal gammopathies [PDF]

Journal of Medical Biochemistry, 2010
The serum immunoglobulin free light chain assay measures levels of free k and l immunoglobulin light chains. There are three major indications for the free light chain assay in the evaluation and management of multiple myeloma and related plasma cell ...
Radović Vesna V.
doaj  

Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin λ light chain

Haematologica, 2007
Disorders of fibrinogen are usually caused by genetic mutations that result in low protein levels (hypofibrinogenemia) or an abnormal molecule (dysfibrinogenemia). However, environmental and plasma factors can have an acquired effect on its expression or
A. Dear, S.O. Brennan, M.J. Sheat, JM. Faed, P.M. George   +4 more
doaj   +1 more source

Skeletal Myopathy as the Initial Manifestation of Light Chain Multiple Myeloma

European Journal of Case Reports in Internal Medicine, 2020
Monoclonal gammopathies due to plasma cell dyscrasias can cause various rare neuromuscular disorders. The peripheral nervous system is most commonly affected, while muscle diseases associated with monoclonal gammopathies are rare. Skeletal myopathy, as a
Mohamed Reda Belkhribchia, Sara Moukhlis, Tarik Bentaoune, Najat Chourkani, Mohamed Zaidani, Mehdi Karkouri   +5 more
doaj   +1 more source

Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]

PLoS ONE, 2018
Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs, Martin Hahn, Lukas Ries, Sophie Giesler, Svenja Busch, Chunlin Wang, Jian Han, Torsten J Schulze, Kerstin Puellmann, Alexander W Beham, Wolfgang E Kaminski, Michael Neumaier   +11 more
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Interaction of a single mode field cavity with the 1D XY model: Energy spectrum [PDF]

Journal of Physics: Conference Series 682 (2016) 012032, 2016
In this work we use the fundamental in quantum optics Jaynes-Cummings model to study the response of spin $\tfrac12$ chain to a single mode of a laser light falling on one of the spins, a focused interaction model between the light and the spin chain. For the spin-spin interaction along the chain we use the XY model. We report here the exact analytical
arxiv   +1 more source