Results 11 to 20 of about 24,521,037 (258)

The synergistic effects of the constant region and variable heavy chain families of multimeric immunoglobulin M on its interaction with Fc-mu receptor and antigen

Exploration of Immunology, 2022
Aim: As the primary response antibody with increasing use as a therapeutic immunoglobulin (Ig) format, IgM is also the largest antibody structure among the five major human isotypes. Spontaneously formed pentamers and hexamers of IgM have avidity effects
Wei-Li Ling, Samuel Ken-En Gan
doaj   +1 more source

Validation of Roche immunoassay for severe acute respiratory coronavirus 2 in South Africa

Southern African Journal of Infectious Diseases, 2021
Background: Serology testing is an important ancillary diagnostic to the reverse transcriptase polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Jurette S. Grove, Elizabeth S. Mayne, Wendy A. Burgers, Jonathan Blackburn, Sarika Jugwanth, Wendy Stevens, Lesley Scott, Anura David, Maemu Gededzha, Ian M. Sanne, Mpho R. Maphayi, Taryn Pillay, Jaya A. George   +12 more
doaj   +1 more source

Serum Immunoglobulins, Pneumonia Risk, and Lung Function in Middle-Aged and Older Individuals: A Population-Based Cohort Study

Frontiers in Immunology, 2022
IntroductionImmunoglobulins (Igs) play a pivotal role in host defense and prevention of pneumonia. Aging influences serum Ig levels, but the association between Igs and pneumonia in community-dwelling older individuals remains unknown.
Samer R. Khan, Samer R. Khan, Anna Vanoverschelde, Anna Vanoverschelde, Lies Lahousse, Lies Lahousse, Robin P. Peeters, Robin P. Peeters, P. Martin van Hagen, P. Martin van Hagen, Guy Brusselle, Guy Brusselle, Guy Brusselle, Layal Chaker, Layal Chaker, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm   +16 more
doaj   +1 more source

Identification of the ancestral killer immunoglobulin-like receptor gene in primates [PDF]

, 2006
Background: Killer Immunoglobulin-like Receptors (KIR) are essential immuno- surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Penny Coggill, Hanne Andersen, Sambrook Jennifer G, Piatak Mike, Carrington Mary, Jennifer G Sambrook, Coggill, P, Stephan Beck, Carrington, M, Piatak, M, Vernikos George S, Mike Piatak, Vernikos, GS, Bashirova Arman, Beck Stephan, Coggill Penny, Bashirova, A, Lifson, JD, Andersen, H, George S Vernikos, Lifson Jeff D, Beck, S, Jeff D Lifson, Andersen Hanne, Arman Bashirova, Mary Carrington, Sambrook, JG   +26 more
core   +1 more source

Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]

, 2004
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M., Farrell, A.M., John M. Darlow, David I. Stott, Stott, D.I., Alex M. Farrell   +5 more
core   +1 more source

Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]

, 1988
The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas, Straubinger, Bernhard, Lötscher, Erika, Zachau, Hans G., Zimmer, Franz-Josef, Jaenichen, Rita, Grzeschik, Karl-Heinz   +6 more
core   +1 more source

Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review

Open Medicine, 2021
Hepatitis A virus immunoglobulin M (HAV-IgM) is often used to diagnose acute hepatitis A virus (HAV) infection serologically. However, false-positive test results can interfere with the diagnosis.
Tan Youwen, Chen Li
doaj   +1 more source

Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement [PDF]

, 2014
Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients
Matthew Buckland (589995), Lorena Lorenzo (589997), Matthew Buckland, Dempster, J, Duraisingham Sai S., Longhurst Hilary J., Matthew Buckl, Sai S. Duraisingham, Sofia Grigoriadou (589998), Sai S Duraisingham, Hilary J Longhurst, John Dempster, Dempster John, Grigoriadou Sofia, Duraisingham, SS, Lorenzo, L, Buckland Matthew, Grigoriadou, S, Sofia Grigoriadou, Lorenzo Lorena, Sai S. Duraisingham (589994), Buckland, M, Longhurst, HJ, Lorena Lorenzo, John Dempster (589996), Hilary J. Longhurst (589999), Hilary J. Longhurst   +26 more
core   +2 more sources

Seroprevalence of Immunoglobulin M and Immunoglobulin G Antibodies Against Rubella Virus Among Women Residing in Southern Iran [PDF]

مجله علوم پزشکی صدرا
Introduction: Maternal rubella infection during the first trimester of pregnancy can have devastating consequences, including fetal death or the birth of infants with severe congenital anomalies. Given the paucity of data regarding rubella immunity among
Navid Omidifar, Mansoureh Shokripour, Mahsa Pakroo, Reza Rahimi, Bahareh Nikmanesh, Erfan Sadeghi, Hassan Akrami, Yousef Nikmanesh   +7 more
doaj   +1 more source

Gene conversion in human rearranged immunoglobulin genes [PDF]

, 2006
Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V_H segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M., John M. Darlow, David I. Stott, Stott, D.I.   +3 more
core   +1 more source