Results 271 to 280 of about 423,364 (313)

Immunoglobulin-M purification — Challenges and perspectives

Biotechnology Advances, 2011
Extensive research in the past two decades has led to the realization of Immunoglobulin-M (IgM) as a potential therapeutic and diagnostic agent. In order to fully exploit the potential of IgM, large quantities, in a highly pure and active form, must be available at low cost for performing clinical trials, characterization studies and quantitative ...
Satyen, Gautam, Kai-Chee, Loh
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Conjugation of Immunoglobulin M to Gold Nanoparticles

Current Nanoscience, 2011
Due to unique optical properties, facile bioconjugation, and biocompatibility, colloidal gold nanoparticles have been widely used for nuclear targeting, gene and drug delivery, and biomedical diagnosis and therapeutics. Various peptides, proteins, and polymers, etc. have been utilized to functionalize gold nanoparticles. Especially antibodies-AuNPs
Wang, Hui, Dimitrov, Krassen
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Selective Immunoglobulin M Deficiency in Foals

Journal of the American Veterinary Medical Association, 1977
SUMMARY Selective immunoglobulin M deficiency was diagnosed in 5 foals, on the basis of reduced serum immunoglobulin M concentrations (more than 2 standard deviations below the normal mean). All 5 foals had clinical signs or lesions involving the respiratory tract.
L E, Perryman, T C, McGuire, B J, Hilbert   +2 more
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Immunoglobulin M in murray valley encephalitis

Pathology, 1975
Twelve clinical cases of Murray Valley encephalitis are described, in which the sero-diagnosis was confirmed by the detection of Murray Valley encephalitis immunoglobulin M.
M A, Wiemers, N D, Stallman
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Piezoelectric immunosensor for the detection of immunoglobulin M

The Analyst, 1995
A piezoelectric immunosensor has been developed for the determination of human IgM. The crystals are AT-cut and have a basic resonant frequency of 9 MHz. Immobilization of goat antihuman IgM antibodies to the crystals' surfaces was accomplished via a CNBr-activated copolymer coating of 2-hydroxyethyl methacrylate and methylmethacrylate.
X, Chu, Z H, Lin, G L, Shen, R Q, Yu
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Evolution of Conformational Flexibility of Immunoglobulin M

1975
Since the initial observations of Heidelberger and Pederson (1) of a macroglobulin antibody against pneumococcus in the horse, IgM has been recognized as a major class of immunoglobulins in mammals as well as in vertebrates as phylogenetically distant as the elasmobranchii (2). In fact, IgM appears to be the first recognizable class to have evolved. It
R E, Cathou, D A, Holowka
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Neutralization by Immunoglobulin M

1993
The pentameric nature of IgM ensures high avidity (about 107-fold greater than Fab) for structures bearing repeated identical antigenic determinants, but in general IgM is of low specificity since its variable region genes are not subject to hypermutation modification that occurs in cells synthesizing IgG or IgA and increases the affinity of these ...
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Adsorptive voltammetric behaviour of immunoglobulin M

Talanta, 1991
The adsorptive voltammetric behaviour of immunoglobulin M (IgM) has been investigated at the static mercury drop electrode. The stripping process yields an analytically useful signal and the detection limit is 1.2 x 10(-10)M. The adsorptive voltammetric behaviour of IgM has been compared with that of IgG and streptavidin.
J M, Fernandez Alvarez, M R, Smyth, R, O'Kennedy   +2 more
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Primary Selective Deficiency of Immunoglobulin M

Internal Medicine Journal, 1978
Summary: Selective deficiency of IgM as a primary disorder is seldom encountered1–3, and the syndrome remains ill‐defined. It is generally accepted that for a diagnosis to be made, the serum IgM level should be consistently below 2 SD of normal, no other immunodeficiencies are present, and it is not secondary to other disease processes. This report of
Y H, Thong, G M, Maxwell
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An allotypic marker on chicken immunoglobulin M

European Journal of Immunology, 1974
AbstractAn allotypic marker, present on IgM, but not IgG, molecules in sera from chickens of the inbred CA, CB and G‐B1 lines, is described. The marker, called “C‐Ml”, is absent in sera from birds of the WA and WB lines, and its segregation in (CB × WA)F2 birds is consistent with its inheritance as a single dominant factor.
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