Results 141 to 150 of about 773,438 (260)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

SOX17/PAX8 dual immunohistochemical expression in the diagnosis of Müllerian carcinomas. [PDF]

Diagn Pathol
Moustafa M, Abdalrahman MAM, Abdelgeleel HM.   +2 more
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

MR-Guided Laser Interstitial Thermal Therapy for Recurrent Glioblastoma: A Case Report With Novel Insights Into Histopathological Changes and Immunological Responses. [PDF]

Neuropathol Appl Neurobiol
Nielsen SH, Artzi SB, Skjøth-Rasmussen J, Larsen CC, Hammouda NM, Larsen KB, Rasmussen R, Hansen AE, Kristensen BW.   +8 more
europepmc   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Differential expression of Wnt5a and β-Catenin in Keratoacanthoma, Verrucous Carcinoma and Well-Differentiated Squamous Cell Carcinoma. [PDF]

Clin Cosmet Investig Dermatol
Zhang Y, Bai X, Ning X, Ren J.
europepmc   +1 more source

Computer-aided techniques for Chromogenic Immunohistochemistry: Status and Directions [PDF]

, 2012
Al-Kofahi, Al-Kofahi, Baggett, Beck, Bogen, Borad, Boykov, Brennan, Brey, Brgmann, Canny, Cheng, Choudhury, Cooper, Cregger, Cross, Cualing, De Solorzano, Demir, Di Cataldo, Di Cataldo, Diaz, Dickinson, DiVito, Dobson, Elisa Ficarra, Elmoataz, Enrico Macii, Ficarra, Ficarra, Ficarra, Flowers, Fuchs, Garrido, Gilbert, Goldstein, Gudla, Gurcan, Gustavson, Hai-Shan Wu, Hama, Han, Hanna, He, Huang, Ingle, Jacob, Kim, Kong, Kurosumi, Lacroix-Triki, Landini, Lehr, Leong, Loos, Luck, Madabhushi, Makretsov, Malpica, Marttila, Masmoudi, Mccullough, Moffitt, Moon, Mueller, Mukherjee, Otsu, Petushi, Pietrini, Queschi, Ramos-Vara, Riera, Roerdink, Rojo, Ruifrok, Santa Di Cataldo, Scholzen, Sharpe, Shi, Shi, Slodkowska, Sompuram, Sun, Taneja, Taylor, Taylor, Theodosiou, Thiran, Tuominen, Umemura, Vonesch, Wang, Ward, Wolff, Woolley, Yang, Zacharaki, Zanella   +97 more
core   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Immunohistochemical Detection of Microglia Using Iba-1 as a Marker in Health and Disease. [PDF]

Sovrem Tekhnologii Med
Guselnikova VV, Kirik OV, Sufieva DA, Razenkova VA, Beketova AA, Korzhevskii DE.   +5 more
europepmc   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source