Results 191 to 200 of about 773,438 (260)

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Primary Cutaneous Rosai-Dorfman Disease With Typical Immunophenotype But Lacking Emperipolesis: A Case Report. [PDF]

Clin Med Insights Case Rep
Al-Soufi L, Marashli A, Younis R, Alkasem AS, Hussein F, Al-Shehabi Z.   +5 more
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Prognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss. [PDF]

Acta Neuropathol Commun
Paterra R, Zago M, Agistri F, Hernandez Gamero G, Mafficini A, Pedron S, Berlendis A, Nozzoli F, Di Meco F, Barresi V.   +9 more
europepmc   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

HER2 Overexpression in Invasive Breast Carcinoma in the Democratic Republic of Congo and its Association with Selected Clinicopathological Characteristics. [PDF]

Breast Cancer (Dove Med Press)
Ilunga Nday G, Ilunga Banza M, Umpungu AN, Kabamba Nzaji M, Moyambe JNT.   +4 more
europepmc   +1 more source

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +1 more source

Immunohistochemical Analysis of Potential Therapeutic Targets PRAME, FOLR1, and CLDN18.2 in Salivary Gland Carcinomas. [PDF]

Cancer Med
Brust LA, Kühn JP, Körner S, Knebel M, Braun FL, Zeidan P, Wemmert S, Schick B, Smola S, Wagner M, Ertz M, Linxweiler M.   +11 more
europepmc   +1 more source

SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway. [PDF]

Int J Oral Sci
Jiang L, Liu L, Yang F, Cui Y, Xie J, Song D, Fan Y, Huang D, Sun J.   +8 more
europepmc   +1 more source

Uterine adenocarcinoma with peritoneal carcinomatosis in a cat: HBME-1 as a potential marker for uterine epithelial disorders in queens. [PDF]

Vet Res Commun
Hartmann G, Lamego ÉC, Paz MC, Bandinelli MB, Pavarini SP.   +4 more
europepmc   +1 more source