Results 191 to 200 of about 5,981,210 (344)

IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN

JCI Insight
Optimization of protective immune responses against SARS-CoV-2 remains an urgent worldwide priority. In this regard, type III IFN (IFN-λ) restricts SARS-CoV-2 infection in vitro, and treatment with IFN-λ limits infection, inflammation, and pathogenesis ...
Abigail D. Solstad, Parker J. Denz, Adam D. Kenney, Najmus S. Mahfooz, Samuel Speaks, Qiaoke Gong, Richard T. Robinson, Matthew E. Long, Adriana Forero, Jacob S. Yount, Emily A. Hemann   +10 more
doaj   +1 more source

Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana. [PDF]

Pediatr Infect Dis J
Dubois MM, Powell M, Schenkel S, Kgole S, Masasa G, Ngwaca M, Phale B, Maphorisa NC, Mohammed T, Moyo S, Molefi T, Makhondo T, Mosiane L, Kololo SO, Sharma T, Jaspan H, Enane LA, Butler LM, Mupfumi L, Christos P, Sundararajan R, Mathad J, Fitzgerald D, Powis K.   +23 more
europepmc   +1 more source

Biopsychosocial Determinants of Hand Function and Its Trajectories Over Five Years in Patients With Hand Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule, Coen van der Meulen, Jos Runhaar, Frits R. Rosendaal, Margreet Kloppenburg   +4 more
wiley   +1 more source

Dysregulated immunologic landscape of the early host response in melioidosis

JCI Insight
Melioidosis, a neglected tropical infection caused by Burkholderia pseudomallei, commonly presents as pneumonia or sepsis with mortality rates up to 50% despite appropriate treatment.
Patpong Rongkard, Lu Xia, Barbara Kronsteiner, Thatcha Yimthin, Rungnapa Phunpang, Adul Dulsuk, Viriya Hantrakun, Gumphol Wongsuvan, Parinya Chamnan, Lara Lovelace-Macon, Emanuele Marchi, Nicholas P.J. Day, Ali Shojaie, Direk Limmathurotsakul, Narisara Chantratita, Paul Klenerman, Susanna J. Dunachie, T. Eoin West, Sina A. Gharib   +18 more
doaj   +1 more source

Granulocyte heterogeneity in immune-mediated and inflammatory diseases: insights from single-cell transcriptomic analyses. [PDF]

Int Immunol
Shimagami H, Kumanogoh A, Nishide M.
europepmc   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Addressing emerging infectious disease threats; a prevention strategy for the United States

Once expected to be eliminated as a public health problem, infectious diseases remain the leading cause of death worldwide. Dramatic changes in society, technology, and the environment together with the diminshed effectiveness of certain approaches to ...

core  

Editorial: Exploring herpesviruses: from biology to disease management and prevention. [PDF]

Front Immunol
Sun C, Zhang H, Wang H, Zhang X.
europepmc   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

From Molecular Pathogenesis to Therapeutic Innovations in Human Cytomegalovirus Research. [PDF]

Pathogens
Damour A, Larribau M, Ligat G.
europepmc   +1 more source