Results 191 to 200 of about 165,216 (289)

ORL@Cu‐MOF Boost Cuproptosis and Suppress Fatty Acid Metabolism for Cancer Lymph Node Metastasis Synergistic Therapy

Advanced Science, EarlyView.
The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li, Yi Liu, Kan Zhou, Lei‐Ming Cao, Guang‐Rui Wang, Jinmei Wu, Yi‐Fu Yu, Yao Xiao, Bing Liu, Qiuji Wu, Zhiyong Song, Lin‐Lin Bu   +11 more
wiley   +1 more source

INHIBITION OF ANGIOGENESIS-RELATED ENDOTHELIAL ACTIVITY BY THE EXPERIMENTAL IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE1

, 2001
W. James Waldman, Alice A. Bickerstaff, Gayle M. Gordillo, Kathleen Orosz, Deborah A. Knight, Charles G. Orosz   +5 more
openalex   +1 more source

CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: Potential role for CB2-selective ligands as immunosuppressive agents [PDF]

, 2006
Catherine Lombard, Prakash Nagarkatti, Prakash Nagarkatti   +2 more
openalex   +1 more source

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Retention time for corticosteroid-sparing systemic immunosuppressive agents in patients with inflammatory eye disease [PDF]

, 2006
Kim Baker, Nicola Spurrier, Angela S. Watkins, Justine R. Smith, J. T. Rosenbaum   +4 more
openalex   +1 more source

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source

Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy. [PDF]

Kidney Res Clin Pract
Choi JY, Chin HJ, Lee H, Jeon Y, Lim JH, Jung HY, Cho JH, Kim CD, Kim YL, Park SH.   +9 more
europepmc   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Nintedanib combined with immunosuppressive agents improves forced vital capacity in connective tissue disease-associated PF-ILD: a single-center study. [PDF]

BMC Rheumatol
Ushio Y, Wakiya R, Kameda T, Nakashima S, Shimada H, Miyagi T, Sugihara K, Mino R, Mizusaki M, Chujo K, Kagawa R, Yamaguchi H, Kadowaki N, Dobashi H.   +13 more
europepmc   +1 more source

Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent fty720

, 2002
Fumin Fu, Shiling Hu, Jeffrey DeLeo, Shu Li, Christine Hopf, Jennifer L. Hoover, Shuya Wang, Volker Brinkmann, Philip Lake, Victor Shi   +9 more
openalex   +1 more source