Results 211 to 220 of about 165,216 (289)

Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy

Advanced Science, EarlyView.
Multiple therapeutic modalities combined in a synergistic way that can modulate different immune axes are demonstrated potentially effective in boosting immunotherapy. A nucleic acid‐locked smart carrier (NASC) performed as an “all‐in‐one” nanoplatform is constructed for efficient eliciting chemo‐ and photothermal‐amplified immunogenic cell death to ...
Jiayang Zhang, Tianyu Gai, Jiwei Wang, Yucai Wu, Si‐Ming Zeng, Dongyuan Zhao, Wei Li   +6 more
wiley   +1 more source

DIFFERENTIAL EFFECTS OF IMMUNOSUPPRESSIVE AGENTS ON RENAL FUNCTION AFTER ISCHEMIA-REPERFUSION INJURY: NEW INSIGHTS BY USING 99MTC-MAG3 IMAGING [PDF]

, 2010
A. Tischer, Tanja Herrler, C. Arszol, Sebastian Nowak, Alexander Haug, S Huber, Peter Bartenstein, Karl-Walther Jauch, Marcus Hacker, Markus Guba   +9 more
openalex   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Immunosuppressive agents for treating IgA nephropathy. [PDF]

Cochrane Database Syst Rev, 2020
Natale P, Palmer SC, Ruospo M, Saglimbene VM, Craig JC, Vecchio M, Samuels JA, Molony DA, Schena FP, Strippoli GF.   +9 more
europepmc   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents. [PDF]

PLoS One, 2020
Kamei K, Miyairi I, Ishikura K, Ogura M, Shoji K, Arai K, Ito R, Kawai T, Ito S.   +8 more
europepmc   +1 more source

LF 15–0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model

, 2003
Dejun Zhou, Catherine O’Brien, Jeffrey Shum, Bertha García, Wei‐Ping Min, Anthony M. Jevnikar, Patrick Dutartre, Robert Zhong   +7 more
openalex   +1 more source

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

Nanosensitizer for Cancer Radioimmunotherapy via Anti‐IL‐35 Blockade Boosted Innate Immunity Activation

Advanced Science, EarlyView.
Zheng et al. designed a tumor microenvironment (TME)‐responsive nanosystem, HmBMH@MSA‐2. It targets tumors, releases MSA‐2 and Mn ions in high glutathione (GSH) conditions, achieving STING agonist delivery and MRI. The nanosystem promotes chemodynamic therapy (CDT), achieves radiosensitization, and activates the cGAS‐STING pathway.
Yinfei Zheng, Shuting Zheng, Yushu Liao, Zede Wu, Chenxi He, Qiuyu Li, Honglei Hu, Zheyu Shen, Yikai Xu, Chenggong Yan, Bingxia Zhao, Meirong Hou   +11 more
wiley   +1 more source