Results 211 to 220 of about 174,772 (308)

Nintedanib combined with immunosuppressive agents improves forced vital capacity in connective tissue disease-associated PF-ILD: a single-center study. [PDF]

BMC Rheumatol
Ushio Y, Wakiya R, Kameda T, Nakashima S, Shimada H, Miyagi T, Sugihara K, Mino R, Mizusaki M, Chujo K, Kagawa R, Yamaguchi H, Kadowaki N, Dobashi H.   +13 more
europepmc   +1 more source

DIFFERENTIAL EFFECTS OF IMMUNOSUPPRESSIVE AGENTS ON RENAL FUNCTION AFTER ISCHEMIA-REPERFUSION INJURY: NEW INSIGHTS BY USING 99MTC-MAG3 IMAGING [PDF]

, 2010
A. Tischer, Tanja Herrler, C. Arszol, Sebastian Nowak, Alexander Haug, S Huber, Peter Bartenstein, Karl-Walther Jauch, Marcus Hacker, Markus Guba   +9 more
openalex   +1 more source

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma

Advanced Science, EarlyView.
BRAF/MEK inhibition promotes extracellular matrix (ECM) accumulation and remodeling during therapy‐tolerant residual disease, limiting CD8⁺ T cell access to tumor cells. Targeting ECM accumulation restores CD8⁺ T cell infiltration, enhances their intratumoral distribution, and delays therapeutic resistance.
Chia‐Hsin Hsu, Jingyi Chen, Keng‐Jung Lee, Leanne R. Donahue, Danielle Kacaj, Sean P. McDonough, Andrew C. White   +6 more
wiley   +1 more source

Impact of varied immunosuppressive agents and post-transplant diabetes mellitus on prognosis among diverse transplant recipients (experimental studies). [PDF]

Int J Surg
Liu Y, Zheng J, He Q, Zhang H, Wen P, Wen P, Ge J, Yang Y, Zhang T, Wang R.   +9 more
europepmc   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

LF 15–0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model

, 2003
Dejun Zhou, Catherine O’Brien, Jeffrey Shum, Bertha García, Wei‐Ping Min, Anthony M. Jevnikar, Patrick Dutartre, Robert Zhong   +7 more
openalex   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Immunosuppressive agents for treating IgA nephropathy. [PDF]

Cochrane Database Syst Rev, 2020
Natale P, Palmer SC, Ruospo M, Saglimbene VM, Craig JC, Vecchio M, Samuels JA, Molony DA, Schena FP, Strippoli GF.   +9 more
europepmc   +1 more source

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source