Results 241 to 250 of about 203,270 (263)
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Immunosuppression in the ERA of Biological Agents
2012Immunosuppression is the mayor mechanism to prevent allograft rejection and to induce tolerance. Since the first solid organ transplant, the development of safe and effective immunosuppressive regimens was a constant over the last decades. A lot of immunosuppressants have been discovered, and today the immunosuppressive agents are classified in two ...
Oriol Bestard +4 more
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Use of immunosuppressive agents in uveitis
Current Opinion in Ophthalmology, 2003This review summarizes current patterns in the use of immunosuppressive agents in patients with uveitis.A number of immunosuppressive agents are currently available for the treatment of uveitis. Reports of safety and efficacy, although numerous, have been largely nonrandomized and performed without controls, limiting, to some extent, the strength and ...
Emmett T. Cunningham, Marc Lustig
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AEB071 – a promising immunosuppressive agent
Clinical Transplantation, 2009Abstract: In the past decades, allograft survival improved because of the development of new and more specific immunosuppressive agents. The introduction of calcineurin inhibitors was a landmark and acute rejection in organ transplantation decreased remarkably.
Martin Zeier, Claudia Sommerer
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CAM—A NOVEL IMMUNOSUPPRESSIVE AGENT
Transplantation, 1995This is an initial study of the immunosuppressive efficacy of CAM, a derivative of mycophenolic acid, in a rat heart allograft model when the major histocompatibility complex was fully incompatible, and its effect in improving heart allograft survival compared with mycophenolate mofetil (MMF, RS-61443).
Hideo Yagita +5 more
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Immunosuppressive agents in organ transplantation
Hospital Medicine, 1999This article reviews current and future immunosuppressive strategies in organ transplantion. Recently introduced drugs are lowering the rates of acute rejection and allowing more individualized management of transplanted patients.
Mark D. Denton +2 more
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The emerging matrix of immunosuppressive agents
Transplantation Proceedings, 2003In recent years, significant milestones have been reached in the field of transplantation through the development of immunosuppressive drugs that inhibit lymphocyte activation, cytokine signal transduction, and cellular proliferation. However, the widespread tissue distribution of the molecular targets exploited to date-calcineurin, mammalian target of
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Opiates as Immunosuppressive and Genotoxic Agents
1991From a historical prospective our immunologic investigations started as a natural consequence of our findings that opiates reduced the genetic integrity of human lymphocytes indicated by evidence of an increased frequency of chromosome damage and a deficiency in DNA repair capacity.
John J. Madden +3 more
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Antineoplastic and Immunosuppressive Agents [PDF]
Tumori Journal, 1975 D.G. Johns, Alan C. Sartorelli
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Evaluation of Immunosuppressive Agents [PDF]
, 1974 Immunosuppressive agents are not by and large a unique class of compounds, but are rather a variety of chemical and biological substances that share the common property of inhibiting the immune response. A knowledge of the biochemical locus of action of a new agent enables a reasonable prediction of its effectiveness as an immunosuppressant ...
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Immunosuppressive Agents in Penetrating Keratoplasty
American Journal of Ophthalmology, 1985One of the problems with corneal grafting is the occurrence of rejection. Immune reaction is considered to be an important cause of graft failure. Early recognition of such graft reaction can frequently be treated successfully with intensive topical administration of corticosteroids.
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