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The emerging matrix of immunosuppressive agents
Transplantation Proceedings, 2003In recent years, significant milestones have been reached in the field of transplantation through the development of immunosuppressive drugs that inhibit lymphocyte activation, cytokine signal transduction, and cellular proliferation. However, the widespread tissue distribution of the molecular targets exploited to date-calcineurin, mammalian target of
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Opiates as Immunosuppressive and Genotoxic Agents
1991From a historical prospective our immunologic investigations started as a natural consequence of our findings that opiates reduced the genetic integrity of human lymphocytes indicated by evidence of an increased frequency of chromosome damage and a deficiency in DNA repair capacity.
John J. Madden +3 more
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Evaluation of Immunosuppressive Agents [PDF]
, 1974 Immunosuppressive agents are not by and large a unique class of compounds, but are rather a variety of chemical and biological substances that share the common property of inhibiting the immune response. A knowledge of the biochemical locus of action of a new agent enables a reasonable prediction of its effectiveness as an immunosuppressant ...
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Antineoplastic and Immunosuppressive Agents [PDF]
Tumori Journal, 1975 D.G. Johns, Alan C. Sartorelli
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BK Virus and Immunosuppressive Agents
2006The last decade has witnessed the introduction of several potent immunosuppressive agents in the field of transplant medicine. Contemporaneously, infection with BK virus (BKV) has emerged as an important complication of immunosuppression and an important cause of allograft loss after kidney transplantation.
Irfan Agha, Daniel C. Brennan
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Immunosuppressive Agents in Penetrating Keratoplasty
American Journal of Ophthalmology, 1985One of the problems with corneal grafting is the occurrence of rejection. Immune reaction is considered to be an important cause of graft failure. Early recognition of such graft reaction can frequently be treated successfully with intensive topical administration of corticosteroids.
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[The generalist and immunosuppressive agents].
Revue medicale de Bruxelles, 2000The general practioneer is frequently concerned by the follow-up of patients receiving immunosuppressive agents for auto-immune diseases or for the prevention of graft rejection. We here review the side effects of the most frequently used immunosuppressive drugs: glucocorticoids, azathioprine, cyclophophamide, cyclosporine and methotrexate.
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Molecular imaging in oncology: Current impact and future directions
Ca-A Cancer Journal for Clinicians, 2022Steven P Rowe, Martin G Pomper
exaly