Results 211 to 220 of about 735,523 (289)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

open access: yesAdvanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac   +7 more
wiley   +1 more source

Adjuvant immunotherapy with transfer factor in patients with melanoma metastatic to lung [PDF]

open access: bronze, 1980
Raymond L. Gonzalez   +2 more
openalex   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

open access: yesAdvanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang   +4 more
wiley   +1 more source

Immunotherapy of genital warts with inosine pranobex and conventional treatment: double blind placebo controlled study. [PDF]

open access: bronze, 1988
J Davidson-Parker   +5 more
openalex   +1 more source

Sound, Force and Light Induced Emissions from Er3+‐Mn2+ Doped ZnS/CaZnOS Heterostructure for Remote Temperature Monitoring via Photo‐ and Mechanoluminescence

open access: yesAdvanced Materials, EarlyView.
Er3⁺/Mn2⁺ co‐doped ZnS/CaZnOS heterostructures are developed for remote temperature and force/sound sensing. The material exhibits UV/NIR photoluminescence, with energy transfer influencing color. Mechanoluminescence intensity is measured against applied power. Temperature‐dependent photoluminescence enabled luminescence thermometry.
Marcin Runowski   +7 more
wiley   +1 more source

A Programmable Nanovaccine Platform Based on M13 Bacteriophage for Personalized Cancer Vaccine and Therapy

open access: yesAdvanced Materials, EarlyView.
A reprogrammed (RP) phage‐based nanovaccine platform has been developed that allows single‐step assembly with precise control over adjuvanticity, antigen density, and nanoparticle size. By enhancing TLR9 activation and neoantigen display, this platform enables a potent personalized vaccine targeting tumor‐specific neoantigens. When combined with immune
Shengnan Huang   +10 more
wiley   +1 more source

CD39 is expressed by a wide range of cutaneous T‐cell lymphomas

open access: yesSkin Health and Disease
Gilles Battesti   +8 more
doaj   +1 more source

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