ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac+7 more
wiley +1 more source
Adjuvant immunotherapy with transfer factor in patients with melanoma metastatic to lung [PDF]
Raymond L. Gonzalez+2 more
openalex +1 more source
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang+4 more
wiley +1 more source
Precise targeting cytotoxicity of antibody-drug conjugate combined with immunotherapy as first-line regimen for metastatic triple-negative breast cancer in ASCENT-04. [PDF]
Bian L, Zhang S, Li M, Yang J, Yin Y.
europepmc +1 more source
A Study on Immunotherapy of Malignant Tumors of the Head and Neck
Kazuyuki Asaoka
openalex +2 more sources
Immunotherapy of genital warts with inosine pranobex and conventional treatment: double blind placebo controlled study. [PDF]
J Davidson-Parker+5 more
openalex +1 more source
Er3⁺/Mn2⁺ co‐doped ZnS/CaZnOS heterostructures are developed for remote temperature and force/sound sensing. The material exhibits UV/NIR photoluminescence, with energy transfer influencing color. Mechanoluminescence intensity is measured against applied power. Temperature‐dependent photoluminescence enabled luminescence thermometry.
Marcin Runowski+7 more
wiley +1 more source
Microwave Ablation Combined With Neoadjuvant Chemotherapy and Immunotherapy in Resectable Stage IIB-IIIB Non-Small Cell Lung Cancer: A Single-Center Retrospective Study. [PDF]
Liu CQ+5 more
europepmc +1 more source
A reprogrammed (RP) phage‐based nanovaccine platform has been developed that allows single‐step assembly with precise control over adjuvanticity, antigen density, and nanoparticle size. By enhancing TLR9 activation and neoantigen display, this platform enables a potent personalized vaccine targeting tumor‐specific neoantigens. When combined with immune
Shengnan Huang+10 more
wiley +1 more source
CD39 is expressed by a wide range of cutaneous T‐cell lymphomas
Gilles Battesti+8 more
doaj +1 more source