Results 61 to 70 of about 7,146,949 (298)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
The Impact of Impact Factors [PDF]
Stroke, 2001 When impact factors rise, editors editorialize. When they fall, editors fall silent. The impact factor of Stroke has risen from 5.53 in 1999 to 6.008 in 2000. It is time to editorialize. These statistics reaffirm Stroke as the leading publication in the field, place it among the top 3 clinical neurological journals along with Brain and the Annals of ...
openaire +2 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
The impact of the impact factor [PDF]
EMBO reports, 2000 As a new journal yet unbranded by an impact factor (IF), we can address this important element of science without suffering either the anguish of those journals that languor in the lower divisions or the insouciance of those with double digit IFs. This number, as abstract as it is, has become the pervasive arbiter of scientific careers for those who ...
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Inequalities in oral health: The economic burden of dental caries
International Dental Journal, 2023 Aim or Purpose: This study aimed to: determine the lifetime costs of preventing and managing of dental caries in five countries (Brazil, Germany, Indonesia, Italy, UK), and assess the impact on these costs from levelling up prevention and management ...
Dr Gerard Dunleavy +9 more
doaj
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Unraveling Concussion Impact by Impact
Journal of Eye Movement Research, 2019 Keynote at the 20th European Conference on Eye Movement Research (ECEM) in Alicante, 20.8.2019.
openaire +4 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source