Results 141 to 150 of about 214,638 (308)

Classical approximation for ionization by heavy particle impact

open access: yes, 1966
Classical binary approximation for ionization by proton ...
Welker, J. E.   +2 more
core  

Observation and Simulation of Mutual Approximations between Five Main Uranian Satellites

open access: yesThe Astronomical Journal
Mutual approximation is an emerging method for obtaining high-precision astrometric measurements of natural satellites and asteroids. We used the 80 cm YaoAn High Precision Telescope to observe mutual approximation events of the main Uranian satellites ...
Jian Chen   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The Approximate Assessment of the Impact of Mining Vibrations on Buildings

open access: yesInżynieria Mineralna
Mining operations, whether underground or surface - based, can lead to a negative phenomenon known as mining tremors. These anthropogenic tremors arise from activities involved in mineral extraction. They can occur in various mining basins, such as the Legnica - Glogow Copper District (LGOM), the Upper Silesian Coal Basin (GZW), and the Lublin Coal ...
Alicja Kowalska - Koczwara   +1 more
openaire   +1 more source

On use of hydrostatic approximation over Greenland

open access: yes, 2003
The modern numerical weather prediction and regional climate simulation modelsfrequently use hydrostatic approximation in the basic primitive equations.
Sood, A. & P. Lemke
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Inventory Management in Multi Echelon Supply Chain Using Sample Average Approximation

open access: yes
An optimization model of multiechelon supply chain is presented in this paper. The decisions to be made are the amount of beer to be ordered in every echelon of supply chain in each echelon over the time horizon of one year.
Soško, Oksana, Plūksne, Nadežda
core  

Analytic and bootstrap approximations of prediction errors under a multivariate fay-herriot model [PDF]

open access: yes, 2005
A Multivariate Fay-Herriot model is used to aid the prediction of small area parameters of dependent variables with sample data aggregated to area level.
Morales, Domingo   +4 more
core  

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