Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Impact Indicators: Overview and Menu Selection
The tool Impact indicators - overview and selection menu was designed by the Evaluating Societal Impact (ESI) strategic project at Erasmus University Rotterdam for academics and research units who want to indicate how their academic work relates to ...
Evaluating Societal Impact
core +1 more source
Piezoelectric Impact Energy Harvester Based on the Composite Spherical Particle Chain for Self-Powered Sensors. [PDF]
Sensors (Basel), 2021 Yang S, Wu B, Liu X, Li M, Wang H, He C.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Energy and dynamic efficiency of single-winding linear electromagnetic motors with a spring drive
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 Relevance of the work is caused by the need to develop the impact machines with the raised power and dynamic indicators for implementing various pulse technologies.
Vladimir Moshkin
doaj
Enhancing Impact Energy Absorption, Flexural and Crash Performance Properties of Automotive Composite Laminates by Adjusting the Stacking Sequences Layup. [PDF]
Polymers (Basel), 2021 Alshahrani H, Ahmed A.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Effect of Process Parameters and Build Orientation on Microstructure and Impact Energy of Electron Beam Powder Bed Fused Ti-6Al-4V. [PDF]
Materials (Basel), 2021 Jeffs S +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Effects of Al Particle Size on the Impact Energy Release of Al-Rich PTFE/Al Composites under Different Strain Rates. [PDF]
Materials (Basel), 2021 Mao L +6 more
europepmc +1 more source