Results 161 to 170 of about 6,621,562 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Impact evaluation of intra-fractional variation on online adaptive radiotherapy for postoperative cervical and endometrial cancer. [PDF]

World J Clin Oncol
Wang GY, Chen YN, Sun YL, Zhou B, Zhang FQ, Yan JF, Hu K.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Finding the balance between academic productivity and impact: evaluation of the Botswana - University of Pennsylvania partnership over a 5-year timeframe. [PDF]

BMJ Glob Health
Cancedda C, Brooks M, Nkomazana O, Keetile M, Ramogola-Masire D, Tsima B, Steenhoff AP, Gross R, Grover S, Lautenbach E, Kebabonye M, Motlhatlhedi K, Ndlovu K, Gaulton G, Barg FK, BUP Evaluation Working Group.   +15 more
europepmc   +1 more source

Impact Evaluation of the Get Healthy in Pregnancy Program: Evidence of Effectiveness. [PDF]

Healthcare (Basel), 2023
McGill B, Lees D, Salisbury J, Reynolds T, Davidson S, Dorney E, Jeong SY, O'Hara BJ.   +7 more
europepmc   +1 more source

PPD impact evaluation report [PDF]

, 2005

core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Geospatial impact evaluation of a low-cost agricultural intervention for enhancing environmental resilience. [PDF]

Int J Appl Earth Obs Geoinf
Khattri P, Sayers R, Singh KK, Slapikas R, Tamang CB, Tamang D, Sagara B, BenYishay A.   +7 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Impact evaluation of technical notes issued by NATJUS on healthcare judicialization. [PDF]

Einstein (Sao Paulo)
Reis Correia L, Nascimento de Paula LG, Trecenti J, Daleffi da Silva B.   +3 more
europepmc   +1 more source