Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Takashi Watari,1– 3 Yasuhisa Nakano,4 Ashwin Gupta,2,3 Minami Kakehi,4 Ayuko Tokonami,4 Yasuharu Tokuda5 1General Medicine Center, Shimane University Hospital, Izumo, Shimane, Japan; 2Department of Medicine, University of Michigan Medical School, Ann ...
Watari T +5 more
doaj
Real-World Impact of Prophylactic Growth Factor Use on Timing of Febrile Neutropenia and Infection After High-Risk Chemotherapy [PDF]
Douglas W. Blayney +8 more
openalex +1 more source
Retraction policies of top scientific journals ranked by impact factor.
OBJECTIVE This study gathered information about the retraction policies of the top 200 scientific journals, ranked by impact factor. METHODS Editors of the top 200 science journals for the year 2012 were contacted by email.
D. Resnik, E. Wager, G. Kissling
semanticscholar +1 more source
Protein kinase FAM20C—when subcellular localization matters
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
The impact factor for the virtual photon to light vector meson transition
We evaluate in the next-to-leading approximation the forward impact factor for the virtual photon to light vector meson transition in the case of longitudinal polarization. We find that in the hard kinematic domain, both in the leading and in the next-to-
A. Papa +28 more
core +1 more source
Journal Impact Factor Shapes Scientists’ Reward Signal in the Prospect of Publication
The incentive structure of a scientist’s life is increasingly mimicking economic principles. While intensely criticized, the journal impact factor (JIF) has taken a role as the new currency for scientists.
F. Paulus +4 more
semanticscholar +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
The Impact of Some Socio-economic Factors on the Nutritional Behavior of Children and Adolescents During the Outbreak of COVID-19: A Case Study of Mashhad, Iran [PDF]
Hossein Moshkabadi Mohajer +2 more
openalex +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source

