Results 41 to 50 of about 2,561,087 (298)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Measuring back: bibliodiversity and the Journal Impact Factor™ brand, a case study of IF-journals included in the 2021 Journal Citations Report™

Insights: The UKSG Journal
Little attention has been devoted to whether the impact factor (IF) can be considered a responsible metric in light of bibliodiversity. This article critically engages with this question in measuring the following variables of IF journals included in the
Marjorie Bardiau, Christophe Dony
doaj   +1 more source

Effect of inclined angle on a vehicle-passenger-inclined highway bridge

Nihon Kikai Gakkai ronbunshu, 2018
This paper presents a theoretical analysis of the dynamic interaction of a vehicle-passenger-inclined highway bridge. The mathematical vehicle-passenger model has 12 degrees of freedom: a vehicle model with four masses has six degrees of freedom, and an ...
Shuji NISHIYAMA, Shinichro OTA
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

The "impact factor" revisited [PDF]

Biomedical Digital Libraries, 2005
Abstract The number of scientific journals has become so large that individuals, institutions and institutional libraries cannot completely store their physical content. In order to prioritize the choice of quality information sources, librarians and scientists are in need of reliable decision aids.
Dong, Peng, Loh, Marie, Mondry, Adrian
openaire   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Variations and impact factors of land use carbon emissions in the Yangtze River Economic Belt from a multiscale perspective

Frontiers in Sustainable Cities
Land use carbon emissions (LUCE) contribute significantly to global warming. Recognizing the influence of regional heterogeneity and geographical scale on socioeconomic development, studying LUCE at various scales is crucial for devising more effective ...
Chong Liu, Xiaoman Wang, Haiyang Li
doaj   +1 more source

Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations

eLife, 2019
We analyzed how often and in what ways the Journal Impact Factor (JIF) is currently used in review, promotion, and tenure (RPT) documents of a representative sample of universities from the United States and Canada. 40% of research-intensive institutions
Erin C McKiernan, Lesley A Schimanski, Carol Muñoz Nieves, Lisa Matthias, Meredith T Niles, Juan P Alperin   +5 more
doaj   +1 more source