Results 111 to 120 of about 1,388,210 (307)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
GeotechnicsThe accurate modeling of dynamic soil–structure interaction processes under impact loading is critical for advancing the design of soil-embedded barrier systems.
Tewodros Y. Yosef +6 more
doaj +1 more source
Metals, 2017 The paper deals with a theoretical and experimental study of the relationship between the microstructural parameters, mechanical properties, and impact deformation and fracture of steels using the example of 17Mn1Si pipe steel.
Dmitry Moiseenko +7 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Barge’s study under impact loads
IOP Conference Series: Materials Science and Engineering, 2019 Abstract The aim of this paper is to present a method of increasing the safety of inner water navigation. It concern on improving the structural resistance of a barge during design process. Numerical structural analyses of the deck and the board are purposed to solve the problem.
M Nechita, C I Mocanu
openaire +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Behavior of soils under impact loading [PDF]
Experimental soil behavior under impact ...
Cox, W. R., Hustad, P. A.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Economic Impact of Container-loading Problem
Transactions on Maritime Science, 2020 Thousands of containers with different types of cargo are loaded every day in multiple manufacturing and logistics centres in the world. The main problem arising from these handlings is how to make the maximum use of all the available container capacities, while keeping the overall costs of transport per cargo unit as low as possible.
openaire +5 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source