Results 121 to 130 of about 8,600,070 (262)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

The impact of dangerous meteorological phenomena on air transport

, 2008
Práce se zaměřuje na dopad nebezpečných meteorologických jevů na leteckou dopravu. Charakterizuje a analyzuje tyto jevy. Z analýzy vyvozuje opatření ke zvýšení bezpečnosti, resp. ke snížení ztrát letecké dopravy.
Svoboda, Martin
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Bogen and Woodward’s data-phenomena distinction, forms of theory-ladenness, and the reliability of data [PDF]

, 2009
Some twenty years ago, Bogen and Woodward challenged one of the fundamental assumptions of the received view, namely the theory-observation dichotomy and argued for the introduction of the further category of scientific phenomena.
Schindler, Samuel
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Some applications of linear response theory to media with mechanical relaxation phenomena

, 2007
The general linear response theory it applied for study mechanical relaxations phenomena in continuous media. It is shown that phenomenological and state coefficients, in viscoanelastic media can be obtained as function of quantities which are ...
Ciancio V., Farsaci F., Ciancio A.
core   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Theory of Change (ToC): A Method for Impact Planning and Assessment

Theory of Change (ToC) is a formative, process-based evaluation method that is most often used to inform or improve project planning. This is a description of the framework based on scientific literature, in which you can learn about Theory of Change ...
Evaluating Societal Impact
core   +1 more source

Fundamentals of interface phenomena in advanced bulk nanoscale materials [PDF]

, 2005
The review is devoted to a study of interface phenomena influencing advanced properties of nanoscale materials processed by means of severe plastic deformation, high-energy ball milling and their combinations.
Sort, J., Suriñach, S., S. Suriæach, S. G. Protasova, Zhilyaev, A. P., M. J. Starink, Ovidko, I.A., Grabovetskaya, G.P., Langdon, T. G., Baró, M. D., Straumal, B.B., J. Gubicza, Langdon, T.G., Révész, Á., Ivanov, M. B., Protasova, S. G., Ungár, T., M. D. Baró, J. Noguøs, G. P. Grabovetskaya, J. Lendvai, Lipnitskii, A.G., Lipnitskii, A. G., Yu. R. Kolobov, N. V. Skiba, Kolobov, Yu.R., Raab, G. I., B. B. Straumal, Gubicza, J., Nazarov, A. A., Mazilkin, A. A., Ivanov, M.B., Skiba, N.V., Protasova, S.G., T. G. Langdon, J. Sort, G. I. Raab, A. A. Nazarov, Raab, G.I., Starink, M.J., Nazarov, A.A., Zhilyaev, A.P., Révész, Ádám, Skiba, N. V., I. A. Ovidko, Baró, M.D., Baretzky, B., Ovidko, I. A., M. B. Ivanov, A. A. Mazilkin, Lendvai, János, Starink, M. J., T. Ungær, Grabovetskaya, G. P., Ungár, Tamás, Kolobov, Yu. R., Nogués, J., Mazilkin, A.A., B. Baretzky, Gubicza, Jenő, Lendvai, J., A. G. Lipnitskii, Straumal, B. B.   +62 more
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