Results 171 to 180 of about 16,071,507 (300)

Correction: Insights into Sudbury's deep architecture: a revised geodynamic model for Earth's largest ore-bearing impact structure. [PDF]

Sci Rep
Haugaard R, Spray JG, Adetunji AQ, Vayavur R, Hamilton MA, Snyder D, Cheraghi S, Ayer J, Henry K, Jørgensen TRC, Serafini G, Smith R, Gibson L.   +12 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Insights into Sudbury's deep architecture: a revised geodynamic model for Earth's largest ore-bearing impact structure. [PDF]

Sci Rep
Haugaard R, Spray JG, Adetunji AQ, Vayavur R, Hamilton MA, Snyder D, Cheraghi S, Ayer J, Henry K, Jørgensen TRC, Serafini G, Smith R, Gibson L.   +12 more
europepmc   +1 more source

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs. [PDF]

J Immunol, 2017
Chamoto K, Guo T, Scally SW, Kagoya Y, Anczurowski M, Wang CH, Rahman MA, Saso K, Butler MO, Chiu PP, Julien JP, Hirano N.   +11 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Deep microbial colonization during impact-generated hydrothermal circulation at the Lappajärvi impact structure, Finland. [PDF]

Nat Commun
Gustafsson J, Osinski GR, Roberts NMW, Quade J, Wang Z, Whitehouse MJ, Jeon H, Karlsson A, Hietala S, Drake H.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of social structure on language structure

The present research advances our understanding of the role of social structure in shaping the ways that language changes over time. We focus on two theories regarding the forces that shape language change: the universal benefit hypothesis, where languages become easier so everyone can comprehend; and the insider benefit hypothesis, where languages ...
openaire   +1 more source

Geology and Mars analog potential of the <2.7-billion-year-old Miralga impact structure, North Pole Dome, Pilbara Craton, Australia. [PDF]

Sci Adv
Brenner AR, Cavosie AJ, Palma-Gomez J, Li J, Kingsbury Lee SA, Fu RR.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source