Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A compliant teleoperation control method based on real-time dynamic impact force feedback and operator-sensing [PDF]
Purpose – In the teleoperating process, the kinematically dissimilar mechanisms of the slave robots and the teleoperation devices will provide unplanned and discontinuous trajectories to the slave robots, which causes jitter on the slave robots that ...
Yiming Bin +5 more
doaj +1 more source
Optimal Execution with Dynamic Order Flow Imbalance [PDF]
We examine optimal execution models that take into account both market microstructure impact and informational costs. Informational footprint is related to order flow and is represented by the trader's influence on the flow imbalance process, while ...
Bechler, Kyle, Ludkovski, Mike
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Guidance Method for Impact Time and Angle Control Based on Trajectory Tracking
To attack a stationary target with both impact time and angle constraints, a guidance method is proposed based on trajectory tracking. According to the constraints of each stage of missile flight, a polynomial missile trajectory satisfying the impact ...
Gang Lei, He Wang, Shaopeng Li
doaj +1 more source
Initial-Condition-Aware Polynomial Guidance with Impact Time and Angle Constraints
With the growing application demands for cooperative guidance systems, the ITAC guidance law has undergone rapid technological advancement in recent research developments.
Xinyao Duan +3 more
doaj +1 more source
Objective To determine the impact of tobacco control policies and mass media campaigns on smoking prevalence in Australian adults. Methods Data for calculating the average monthly prevalence of smoking between January 2001 and June 2011 were obtained ...
Melanie A Wakefield +7 more
doaj +1 more source
Transportation Costs and U.S. Manufacturing FDI [PDF]
In empirical models of foreign direct investment (FDI), distance is most often used to proxy for transportation costs and other pure-trade costs.
Daniels, Joseph P., Ruhr, Marc von der
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Reliability and Test Differences for the Impact: Implications for Concussion Testing Programs
This study was conducted to determine the long-term relatability of ImPACT scores among young athletes. Youth sport participants (n=294) who completed ImPACT tests one year apart were included in the study.
Koch, Christopher, Robertson, Sean
core

