Results 121 to 130 of about 12,955,611 (331)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. Sterility testing of advanced therapy medicinal products (ATMP) implies several challenges, including limited volume of available sample, product sensitivity to test conditions, and short shelf life.
M. V. Roshchina +2 more
doaj +1 more source
Divorce and the birth control pill [PDF]
This paper explores the role of the birth control pill on divorce. To identify its effect, we use a quasi experiment exploiting the differences in the language of the Comstock anti-obscenity statutes approved in the 1800s and early 1900s in the US ...
MARCÉN, MIRIAM
core +1 more source
Scalable Co-Optimization of Morphology and Control in Embodied Machines
, 2017 Evolution sculpts both the body plans and nervous systems of agents together over time. In contrast, in AI and robotics, a robot's body plan is usually designed by hand, and control policies are then optimized for that fixed design.
Bongard, Josh +3 more
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Impact Assessment of Hypothesized Cyberattacks on Interconnected Bulk Power Systems
, 2018 The first-ever Ukraine cyberattack on power grid has proven its devastation by hacking into their critical cyber assets. With administrative privileges accessing substation networks/local control centers, one intelligent way of coordinated cyberattacks ...
Ginter, Andrew +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Nonlinear Three-Dimensional Guidance for Impact Time and Angle Control With Field-of-View Constraint
IEEE Transactions on Aerospace and Electronic SystemsThis article presents a nonlinear 3-D guidance law for homing missiles with a field-of-view (FOV) constraint to achieve impact time and angle control against a stationary target.
Pengyu Wang +3 more
semanticscholar +1 more source
Impact-Aware Control using Time-Invariant Reference Spreading
15 pages, 10 figures. Submitted to IEEE Transactions on Robotics (T-RO)
van Steen, Jari +2 more
openaire +2 more sources